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Yokukan-san: a review of the evidence for use of this Kampo herbal formula in dementia and psychiatric conditions

Japanese traditional herbal medicine (Kampo) has its origins in traditional Chinese medicine (TCM). It was introduced to Japan in the middle of the sixth century and has evolved over the past 1,400 years after combining with Japan’s original folk remedies. While it retains some similarities to TCM,...

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Autores principales: Okamoto, Hideki, Iyo, Masaomi, Ueda, Keigo, Han, Cheolsun, Hirasaki, Yoshiro, Namiki, Takao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4168872/
https://www.ncbi.nlm.nih.gov/pubmed/25246794
http://dx.doi.org/10.2147/NDT.S65257
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author Okamoto, Hideki
Iyo, Masaomi
Ueda, Keigo
Han, Cheolsun
Hirasaki, Yoshiro
Namiki, Takao
author_facet Okamoto, Hideki
Iyo, Masaomi
Ueda, Keigo
Han, Cheolsun
Hirasaki, Yoshiro
Namiki, Takao
author_sort Okamoto, Hideki
collection PubMed
description Japanese traditional herbal medicine (Kampo) has its origins in traditional Chinese medicine (TCM). It was introduced to Japan in the middle of the sixth century and has evolved over the past 1,400 years after combining with Japan’s original folk remedies. While it retains some similarities to TCM, Kampo has evolved in Japan, resulting in a system of medicine that has many differences from TCM. Kampo medicine is considered to be very safe; in Japan, Kampo herbal formulas are manufactured by licensed pharmaceutical companies, prescribed by Western-trained medical doctors (usually as a freeze-dried extract), and have quality control standards similar to those of prescription drugs. The present study examined Yokukan-san (Yi-Gan San in TCM), a Kampo formula that has been used empirically in Japan for more than 400 years. Accumulating clinical trials have demonstrated Yokukan-san’s efficacy in treating patients with behavioral and psychological symptoms of dementia, which has resulted in the Japanese Society of Neurology listing it in the Japanese Guidelines for the Management of Dementia 2010. Efficacy in other diseases and conditions, such as sleep disorders, tardive dyskinesia, aggression, and impulsivity has also been reported. This article reviews both clinical and basic studies of Yokukan-san, with the goal of clarifying its clinical indications.
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spelling pubmed-41688722014-09-22 Yokukan-san: a review of the evidence for use of this Kampo herbal formula in dementia and psychiatric conditions Okamoto, Hideki Iyo, Masaomi Ueda, Keigo Han, Cheolsun Hirasaki, Yoshiro Namiki, Takao Neuropsychiatr Dis Treat Review Japanese traditional herbal medicine (Kampo) has its origins in traditional Chinese medicine (TCM). It was introduced to Japan in the middle of the sixth century and has evolved over the past 1,400 years after combining with Japan’s original folk remedies. While it retains some similarities to TCM, Kampo has evolved in Japan, resulting in a system of medicine that has many differences from TCM. Kampo medicine is considered to be very safe; in Japan, Kampo herbal formulas are manufactured by licensed pharmaceutical companies, prescribed by Western-trained medical doctors (usually as a freeze-dried extract), and have quality control standards similar to those of prescription drugs. The present study examined Yokukan-san (Yi-Gan San in TCM), a Kampo formula that has been used empirically in Japan for more than 400 years. Accumulating clinical trials have demonstrated Yokukan-san’s efficacy in treating patients with behavioral and psychological symptoms of dementia, which has resulted in the Japanese Society of Neurology listing it in the Japanese Guidelines for the Management of Dementia 2010. Efficacy in other diseases and conditions, such as sleep disorders, tardive dyskinesia, aggression, and impulsivity has also been reported. This article reviews both clinical and basic studies of Yokukan-san, with the goal of clarifying its clinical indications. Dove Medical Press 2014-09-12 /pmc/articles/PMC4168872/ /pubmed/25246794 http://dx.doi.org/10.2147/NDT.S65257 Text en © 2014 Okamoto et al. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.
spellingShingle Review
Okamoto, Hideki
Iyo, Masaomi
Ueda, Keigo
Han, Cheolsun
Hirasaki, Yoshiro
Namiki, Takao
Yokukan-san: a review of the evidence for use of this Kampo herbal formula in dementia and psychiatric conditions
title Yokukan-san: a review of the evidence for use of this Kampo herbal formula in dementia and psychiatric conditions
title_full Yokukan-san: a review of the evidence for use of this Kampo herbal formula in dementia and psychiatric conditions
title_fullStr Yokukan-san: a review of the evidence for use of this Kampo herbal formula in dementia and psychiatric conditions
title_full_unstemmed Yokukan-san: a review of the evidence for use of this Kampo herbal formula in dementia and psychiatric conditions
title_short Yokukan-san: a review of the evidence for use of this Kampo herbal formula in dementia and psychiatric conditions
title_sort yokukan-san: a review of the evidence for use of this kampo herbal formula in dementia and psychiatric conditions
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4168872/
https://www.ncbi.nlm.nih.gov/pubmed/25246794
http://dx.doi.org/10.2147/NDT.S65257
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