Synthesis of α-amino amidines through molecular iodine-catalyzed three-component coupling of isocyanides, aldehydes and amines

A facile and efficient synthetic protocol for the synthesis of α-amino amidines has been developed using a molecular iodine-catalyzed three-component coupling reaction of isocyanides, amines, and aldehydes. The presented strategy offers the advantages of mild reaction conditions, low environmental i...

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Detalles Bibliográficos
Autores principales: Adiyala, Praveen Reddy, Chandrasekhar, D, Kapure, Jeevak Sopanrao, Reddy, Chada Narsimha, Maurya, Ram Awatar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Beilstein-Institut 2014
Materias:
Full Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4168875/
https://www.ncbi.nlm.nih.gov/pubmed/25246965
http://dx.doi.org/10.3762/bjoc.10.214
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author Adiyala, Praveen Reddy
Chandrasekhar, D
Kapure, Jeevak Sopanrao
Reddy, Chada Narsimha
Maurya, Ram Awatar
author_facet Adiyala, Praveen Reddy
Chandrasekhar, D
Kapure, Jeevak Sopanrao
Reddy, Chada Narsimha
Maurya, Ram Awatar
author_sort Adiyala, Praveen Reddy
collection PubMed
description A facile and efficient synthetic protocol for the synthesis of α-amino amidines has been developed using a molecular iodine-catalyzed three-component coupling reaction of isocyanides, amines, and aldehydes. The presented strategy offers the advantages of mild reaction conditions, low environmental impact, clean and simple methodology, high atom economy, wide substrate scope and high yields.
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spelling pubmed-41688752014-09-22 Synthesis of α-amino amidines through molecular iodine-catalyzed three-component coupling of isocyanides, aldehydes and amines Adiyala, Praveen Reddy Chandrasekhar, D Kapure, Jeevak Sopanrao Reddy, Chada Narsimha Maurya, Ram Awatar Beilstein J Org Chem Full Research Paper A facile and efficient synthetic protocol for the synthesis of α-amino amidines has been developed using a molecular iodine-catalyzed three-component coupling reaction of isocyanides, amines, and aldehydes. The presented strategy offers the advantages of mild reaction conditions, low environmental impact, clean and simple methodology, high atom economy, wide substrate scope and high yields. Beilstein-Institut 2014-09-02 /pmc/articles/PMC4168875/ /pubmed/25246965 http://dx.doi.org/10.3762/bjoc.10.214 Text en Copyright © 2014, Adiyala et al. https://creativecommons.org/licenses/by/2.0https://www.beilstein-journals.org/bjoc/termsThis is an Open Access article under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The license is subject to the Beilstein Journal of Organic Chemistry terms and conditions: (https://www.beilstein-journals.org/bjoc/terms)
spellingShingle Full Research Paper
Adiyala, Praveen Reddy
Chandrasekhar, D
Kapure, Jeevak Sopanrao
Reddy, Chada Narsimha
Maurya, Ram Awatar
Synthesis of α-amino amidines through molecular iodine-catalyzed three-component coupling of isocyanides, aldehydes and amines
title Synthesis of α-amino amidines through molecular iodine-catalyzed three-component coupling of isocyanides, aldehydes and amines
title_full Synthesis of α-amino amidines through molecular iodine-catalyzed three-component coupling of isocyanides, aldehydes and amines
title_fullStr Synthesis of α-amino amidines through molecular iodine-catalyzed three-component coupling of isocyanides, aldehydes and amines
title_full_unstemmed Synthesis of α-amino amidines through molecular iodine-catalyzed three-component coupling of isocyanides, aldehydes and amines
title_short Synthesis of α-amino amidines through molecular iodine-catalyzed three-component coupling of isocyanides, aldehydes and amines
title_sort synthesis of α-amino amidines through molecular iodine-catalyzed three-component coupling of isocyanides, aldehydes and amines
topic Full Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4168875/
https://www.ncbi.nlm.nih.gov/pubmed/25246965
http://dx.doi.org/10.3762/bjoc.10.214
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