Cargando…
N–O Cleavage reactions of heterobicycloalkene-fused 2-isoxazolines
Transition metal-mediated N–O bond cleavage reactions of heterobicycloalkene-fused 3-methyl-2-isoxazolines were investigated. Optimal cleavage conditions were found with Raney nickel/AlCl(3) mediation in aqueous methanol. The reaction provided a diverse collection of novel heterobicycle-fused β-hydr...
| Autores principales: | , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Beilstein-Institut
2014
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4168885/ https://www.ncbi.nlm.nih.gov/pubmed/25246978 http://dx.doi.org/10.3762/bjoc.10.227 |
| Sumario: | Transition metal-mediated N–O bond cleavage reactions of heterobicycloalkene-fused 3-methyl-2-isoxazolines were investigated. Optimal cleavage conditions were found with Raney nickel/AlCl(3) mediation in aqueous methanol. The reaction provided a diverse collection of novel heterobicycle-fused β-hydroxyketones with good to excellent yields (66–95%) and without the need for chromatographic purification. |
|---|