Examining Variable Domain Orientations in Antigen Receptors Gives Insight into TCR-Like Antibody Design

The variable domains of antibodies and T-Cell receptors (TCRs) share similar structures. Both molecules act as sensors for the immune system but recognise their respective antigens in different ways. Antibodies bind to a diverse set of antigenic shapes whilst TCRs only recognise linear peptides pres...

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Detalles Bibliográficos
Autores principales: Dunbar, James, Knapp, Bernhard, Fuchs, Angelika, Shi, Jiye, Deane, Charlotte M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4168974/
https://www.ncbi.nlm.nih.gov/pubmed/25233457
http://dx.doi.org/10.1371/journal.pcbi.1003852

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4168974/
https://www.ncbi.nlm.nih.gov/pubmed/25233457
http://dx.doi.org/10.1371/journal.pcbi.1003852

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