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Examining Variable Domain Orientations in Antigen Receptors Gives Insight into TCR-Like Antibody Design
The variable domains of antibodies and T-Cell receptors (TCRs) share similar structures. Both molecules act as sensors for the immune system but recognise their respective antigens in different ways. Antibodies bind to a diverse set of antigenic shapes whilst TCRs only recognise linear peptides pres...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2014
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4168974/ https://www.ncbi.nlm.nih.gov/pubmed/25233457 http://dx.doi.org/10.1371/journal.pcbi.1003852 |