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Tubulointerstitial nephritis and uveitis syndrome complicated by IgA nephropathy and Graves’ disease: a case report

INTRODUCTION: Tubulointerstitial nephritis and uveitis syndrome is a disorder characterized by a combination of acute tubulointerstitial nephritis and uveitis. Immunoglobulin A nephropathy is defined by the presence of immunoglobulin A deposits in glomerular mesangial areas. In this report, we descr...

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Autores principales: Shimamura, Yoshinosuke, Tsushima, Takahiro, Moniwa, Norihito, Hasegawa, Koichi, Ogawa, Yayoi, Takizawa, Hideki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4168995/
https://www.ncbi.nlm.nih.gov/pubmed/25216854
http://dx.doi.org/10.1186/1752-1947-8-305
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author Shimamura, Yoshinosuke
Tsushima, Takahiro
Moniwa, Norihito
Hasegawa, Koichi
Ogawa, Yayoi
Takizawa, Hideki
author_facet Shimamura, Yoshinosuke
Tsushima, Takahiro
Moniwa, Norihito
Hasegawa, Koichi
Ogawa, Yayoi
Takizawa, Hideki
author_sort Shimamura, Yoshinosuke
collection PubMed
description INTRODUCTION: Tubulointerstitial nephritis and uveitis syndrome is a disorder characterized by a combination of acute tubulointerstitial nephritis and uveitis. Immunoglobulin A nephropathy is defined by the presence of immunoglobulin A deposits in glomerular mesangial areas. In this report, we describe a rare case of tubulointerstitial nephritis and uveitis syndrome complicated by immunoglobulin A nephropathy and Graves’ disease, which was successfully treated with corticosteroids. To the best of our knowledge, this is the first time such a case has been documented since tubulointerstitial nephritis and uveitis syndrome was first described. CASE PRESENTATION: A 64-year-old Japanese woman presented with tubulointerstitial nephritis and uveitis syndrome accompanied by immunoglobulin A nephropathy and Graves’ disease. She had renal dysfunction, proteinuria, and hematuria. Two weeks after her admission, she developed anterior chamber uveitis. She received corticosteroids, resulting in significant clinical improvement. CONCLUSION: Tubulointerstitial nephritis and uveitis syndrome is a relatively uncommon cause of tubulointerstitial nephritis. Clinicians should recognize that tubulointerstitial nephritis and uveitis syndrome with immunoglobulin A nephropathy can occur in the presence of Graves’ disease. Additionally, this report may provide important clues in terms of the management of a concomitant case of these diseases.
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spelling pubmed-41689952014-09-20 Tubulointerstitial nephritis and uveitis syndrome complicated by IgA nephropathy and Graves’ disease: a case report Shimamura, Yoshinosuke Tsushima, Takahiro Moniwa, Norihito Hasegawa, Koichi Ogawa, Yayoi Takizawa, Hideki J Med Case Rep Case Report INTRODUCTION: Tubulointerstitial nephritis and uveitis syndrome is a disorder characterized by a combination of acute tubulointerstitial nephritis and uveitis. Immunoglobulin A nephropathy is defined by the presence of immunoglobulin A deposits in glomerular mesangial areas. In this report, we describe a rare case of tubulointerstitial nephritis and uveitis syndrome complicated by immunoglobulin A nephropathy and Graves’ disease, which was successfully treated with corticosteroids. To the best of our knowledge, this is the first time such a case has been documented since tubulointerstitial nephritis and uveitis syndrome was first described. CASE PRESENTATION: A 64-year-old Japanese woman presented with tubulointerstitial nephritis and uveitis syndrome accompanied by immunoglobulin A nephropathy and Graves’ disease. She had renal dysfunction, proteinuria, and hematuria. Two weeks after her admission, she developed anterior chamber uveitis. She received corticosteroids, resulting in significant clinical improvement. CONCLUSION: Tubulointerstitial nephritis and uveitis syndrome is a relatively uncommon cause of tubulointerstitial nephritis. Clinicians should recognize that tubulointerstitial nephritis and uveitis syndrome with immunoglobulin A nephropathy can occur in the presence of Graves’ disease. Additionally, this report may provide important clues in terms of the management of a concomitant case of these diseases. BioMed Central 2014-09-12 /pmc/articles/PMC4168995/ /pubmed/25216854 http://dx.doi.org/10.1186/1752-1947-8-305 Text en Copyright © 2014 Shimamura et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/4.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Case Report
Shimamura, Yoshinosuke
Tsushima, Takahiro
Moniwa, Norihito
Hasegawa, Koichi
Ogawa, Yayoi
Takizawa, Hideki
Tubulointerstitial nephritis and uveitis syndrome complicated by IgA nephropathy and Graves’ disease: a case report
title Tubulointerstitial nephritis and uveitis syndrome complicated by IgA nephropathy and Graves’ disease: a case report
title_full Tubulointerstitial nephritis and uveitis syndrome complicated by IgA nephropathy and Graves’ disease: a case report
title_fullStr Tubulointerstitial nephritis and uveitis syndrome complicated by IgA nephropathy and Graves’ disease: a case report
title_full_unstemmed Tubulointerstitial nephritis and uveitis syndrome complicated by IgA nephropathy and Graves’ disease: a case report
title_short Tubulointerstitial nephritis and uveitis syndrome complicated by IgA nephropathy and Graves’ disease: a case report
title_sort tubulointerstitial nephritis and uveitis syndrome complicated by iga nephropathy and graves’ disease: a case report
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4168995/
https://www.ncbi.nlm.nih.gov/pubmed/25216854
http://dx.doi.org/10.1186/1752-1947-8-305
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