Removal of a C-terminal serine residue proximal to the inter-chain disulfide bond of a human IgG1 lambda light chain mediates enhanced antibody stability and antibody dependent cell-mediated cytotoxicity

Optimization of biophysical properties is a critical success factor for the developability of monoclonal antibodies with potential therapeutic applications. The inter-domain disulfide bond between light chain (Lc) and heavy chain (Hc) in human IgG1 lends structural support for antibody scaffold stab...

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Detalles Bibliográficos
Autores principales: Shen, Yang, Zeng, Lin, Zhu, Aiping, Blanc, Tim, Patel, Dipa, Pennello, Anthony, Bari, Amtul, Ng, Stanley, Persaud, Kris, Kang, Yun (Kenneth), Balderes, Paul, Surguladze, David, Hindi, Sagit, Zhou, Qinwei, Ludwig, Dale L., Snavely, Marshall
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2013
Materias:
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4169035/
https://www.ncbi.nlm.nih.gov/pubmed/23567210
http://dx.doi.org/10.4161/mabs.24291

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