Selective optical drive of thalamic reticular nucleus generates thalamic bursts & cortical spindles

The thalamic reticular nucleus (TRN) is hypothesized to regulate neocortical rhythms and behavioral state. Using optogenetics and multi-electrode recording in behaving mice, we found that brief selective drive of TRN switched thalamocortical firing mode from tonic to bursting and generated state-dep...

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Autores principales: Halassa, Michael M., Siegle, Joshua H., Ritt, Jason T., Ting, Jonathan T., Feng, Guoping, Moore, Christopher I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4169194/
https://www.ncbi.nlm.nih.gov/pubmed/21785436
http://dx.doi.org/10.1038/nn.2880
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author Halassa, Michael M.
Siegle, Joshua H.
Ritt, Jason T.
Ting, Jonathan T.
Feng, Guoping
Moore, Christopher I.
author_facet Halassa, Michael M.
Siegle, Joshua H.
Ritt, Jason T.
Ting, Jonathan T.
Feng, Guoping
Moore, Christopher I.
author_sort Halassa, Michael M.
collection PubMed
description The thalamic reticular nucleus (TRN) is hypothesized to regulate neocortical rhythms and behavioral state. Using optogenetics and multi-electrode recording in behaving mice, we found that brief selective drive of TRN switched thalamocortical firing mode from tonic to bursting and generated state-dependent neocortical spindles. These findings provide causal support for the TRN in state-regulation in vivo and introduce a new model for addressing the role of this structure in behavior.
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spelling pubmed-41691942014-09-19 Selective optical drive of thalamic reticular nucleus generates thalamic bursts & cortical spindles Halassa, Michael M. Siegle, Joshua H. Ritt, Jason T. Ting, Jonathan T. Feng, Guoping Moore, Christopher I. Nat Neurosci Article The thalamic reticular nucleus (TRN) is hypothesized to regulate neocortical rhythms and behavioral state. Using optogenetics and multi-electrode recording in behaving mice, we found that brief selective drive of TRN switched thalamocortical firing mode from tonic to bursting and generated state-dependent neocortical spindles. These findings provide causal support for the TRN in state-regulation in vivo and introduce a new model for addressing the role of this structure in behavior. 2011-07-24 /pmc/articles/PMC4169194/ /pubmed/21785436 http://dx.doi.org/10.1038/nn.2880 Text en Users may view, print, copy, download and text and data- mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use: http://www.nature.com/authors/editorial_policies/license.html#terms
spellingShingle Article
Halassa, Michael M.
Siegle, Joshua H.
Ritt, Jason T.
Ting, Jonathan T.
Feng, Guoping
Moore, Christopher I.
Selective optical drive of thalamic reticular nucleus generates thalamic bursts & cortical spindles
title Selective optical drive of thalamic reticular nucleus generates thalamic bursts & cortical spindles
title_full Selective optical drive of thalamic reticular nucleus generates thalamic bursts & cortical spindles
title_fullStr Selective optical drive of thalamic reticular nucleus generates thalamic bursts & cortical spindles
title_full_unstemmed Selective optical drive of thalamic reticular nucleus generates thalamic bursts & cortical spindles
title_short Selective optical drive of thalamic reticular nucleus generates thalamic bursts & cortical spindles
title_sort selective optical drive of thalamic reticular nucleus generates thalamic bursts & cortical spindles
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4169194/
https://www.ncbi.nlm.nih.gov/pubmed/21785436
http://dx.doi.org/10.1038/nn.2880
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