The Association of the Vanin-1 N131S Variant with Blood Pressure Is Mediated by Endoplasmic Reticulum-Associated Degradation and Loss of Function

High blood pressure (BP) is the most common cardiovascular risk factor worldwide and a major contributor to heart disease and stroke. We previously discovered a BP-associated missense SNP (single nucleotide polymorphism)–rs2272996–in the gene encoding vanin-1, a glycosylphosphatidylinositol (GPI)-an...

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Detalles Bibliográficos
Autores principales: Wang, Ya-Juan, Tayo, Bamidele O., Bandyopadhyay, Anupam, Wang, Heming, Feng, Tao, Franceschini, Nora, Tang, Hua, Gao, Jianmin, Sung, Yun Ju, Elston, Robert C., Williams, Scott M., Cooper, Richard S., Mu, Ting-Wei, Zhu, Xiaofeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4169380/
https://www.ncbi.nlm.nih.gov/pubmed/25233454
http://dx.doi.org/10.1371/journal.pgen.1004641

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