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tRNA Modifying Enzymes, NSUN2 and METTL1, Determine Sensitivity to 5-Fluorouracil in HeLa Cells

Nonessential tRNA modifications by methyltransferases are evolutionarily conserved and have been reported to stabilize mature tRNA molecules and prevent rapid tRNA decay (RTD). The tRNA modifying enzymes, NSUN2 and METTL1, are mammalian orthologs of yeast Trm4 and Trm8, which are required for protec...

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Detalles Bibliográficos
Autores principales:	Okamoto, Mayumi, Fujiwara, Mamoru, Hori, Masato, Okada, Kaoru, Yazama, Futoshi, Konishi, Hiroaki, Xiao, Yegui, Qi, Guangying, Shimamoto, Fumio, Ota, Takahide, Temme, Achim, Tatsuka, Masaaki
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4169382/ https://www.ncbi.nlm.nih.gov/pubmed/25233213 http://dx.doi.org/10.1371/journal.pgen.1004639

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