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An Efficient, Optimized Synthesis of Fentanyl and Related Analogs
The alternate and optimized syntheses of the parent opioid fentanyl and its analogs are described. The routes presented exhibit high-yielding transformations leading to these powerful analgesics after optimization studies were carried out for each synthetic step. The general three-step strategy prod...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2014
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4169472/ https://www.ncbi.nlm.nih.gov/pubmed/25233364 http://dx.doi.org/10.1371/journal.pone.0108250 |