The Strong In Vivo Anti-Tumor Effect of the UIC2 Monoclonal Antibody Is the Combined Result of Pgp Inhibition and Antibody Dependent Cell-Mediated Cytotoxicity

P-glycoprotein (Pgp) extrudes a large variety of chemotherapeutic drugs from the cells, causing multidrug resistance (MDR). The UIC2 monoclonal antibody recognizes human Pgp and inhibits its drug transport activity. However, this inhibition is partial, since UIC2 binds only to 10–40% of cell surface...

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Detalles Bibliográficos
Autores principales: Szalóki, Gábor, Krasznai, Zoárd T., Tóth, Ágnes, Vízkeleti, Laura, Szöllősi, Attila G., Trencsényi, György, Lajtos, Imre, Juhász, István, Krasznai, Zoltán, Márián, Teréz, Balázs, Margit, Szabó, Gábor, Goda, Katalin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4169599/
https://www.ncbi.nlm.nih.gov/pubmed/25238617
http://dx.doi.org/10.1371/journal.pone.0107875

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