Cargando…

A New Ibuprofen Derivative Inhibits Platelet Aggregation and ROS Mediated Platelet Apoptosis

Thrombocytopenia is a serious issue connected with the pathogenesis of several human diseases including chronic inflammation, arthritis, Alzheimer's disease, cardiovascular diseases (CVDs) and other oxidative stress-associated pathologies. The indiscriminate use of antibiotics and other biologi...

Descripción completa

Detalles Bibliográficos
Autores principales:	Rakesh, Kodagahalli S., Jagadish, Swamy, Vinayaka, Ajjampura C., Hemshekhar, Mahadevappa, Paul, Manoj, Thushara, Ram M., Sundaram, Mahalingam S., Swaroop, Toreshettahally R., Mohan, Chakrabhavi D., Basappa, Sadashiva, Marilinganadoddi P., Kemparaju, Kempaiah, Girish, Kesturu S., Rangappa, Kanchugarakoppal S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4169656/ https://www.ncbi.nlm.nih.gov/pubmed/25238069 http://dx.doi.org/10.1371/journal.pone.0107182

Ejemplares similares

Unconjugated Bilirubin exerts Pro-Apoptotic Effect on Platelets via p38-MAPK activation
por: NaveenKumar, Somanathapura K., et al.
Publicado: (2015)

Novel Benzoxazine-Based Aglycones Block Glucose Uptake In Vivo by Inhibiting Glycosidases
por: Bharathkumar, Hanumantharayappa, et al.
Publicado: (2014)

Novel Apigenin Based Small Molecule that Targets Snake Venom Metalloproteases
por: Srinivasa, Venkatachalaiah, et al.
Publicado: (2014)

Methotrexate Promotes Platelet Apoptosis via JNK-Mediated Mitochondrial Damage: Alleviation by N-Acetylcysteine and N-Acetylcysteine Amide
por: Paul, Manoj, et al.
Publicado: (2015)

Tamarind Seed (Tamarindus indica) Extract Ameliorates Adjuvant-Induced Arthritis via Regulating the Mediators of Cartilage/Bone Degeneration, Inflammation and Oxidative Stress
por: Sundaram, Mahalingam S., et al.
Publicado: (2015)

A One Pot Synthesis of Novel Bioactive Tri-Substitute-Condensed-Imidazopyridines that Targets Snake Venom Phospholipase A(2)
por: Anilkumar, Nirvanappa C., et al.
Publicado: (2015)

Novel Synthetic Oxazines Target NF-κB in Colon Cancer In Vitro and Inflammatory Bowel Disease In Vivo
por: Nirvanappa, Anilkumar C., et al.
Publicado: (2016)

Correction: Novel Synthetic Oxazines Target NF-κB in Colon Cancer In Vitro and Inflammatory Bowel Disease In Vivo
por: Nirvanappa, Anilkumar C., et al.
Publicado: (2017)

A panoramic view on synthetic applications of α-oxothioamides: a highly regioselective synthesis of 2-acyl-4-(het)arylthiazoles and thioethers
por: Suresh, Rajaghatta N., et al.
Publicado: (2023)

Reply to ‘Evidence that neutrophils do not promote Echis carinatus venom-induced tissue destruction’
por: Kemparaju, Kempaiah, et al.
Publicado: (2018)

Phytochemicals as Invaluable Sources of Potent Antimicrobial Agents to Combat Antibiotic Resistance
por: Jadimurthy, Ragi, et al.
Publicado: (2023)

New Heparanase-Inhibiting Triazolo-Thiadiazoles Attenuate Primary Tumor Growth and Metastasis
por: Barash, Uri, et al.
Publicado: (2021)

Development of Novel Triazolo-Thiadiazoles from Heterogeneous “Green” Catalysis as Protein Tyrosine Phosphatase 1B Inhibitors
por: Baburajeev, C. P., et al.
Publicado: (2015)

Research into the Causes of Venom-Induced Mortality and Morbidity Identifies New Therapeutic Opportunities
por: Girish, Kesturu S., et al.
Publicado: (2019)

A comparative cross-reactivity and paraspecific neutralization study on Hypnale hypnale, Echis carinatus, and Daboia russelii monovalent and therapeutic polyvalent anti-venoms
por: Sandesha, Vaddaragudisalu D., et al.
Publicado: (2022)

The reaction of arylmethyl isocyanides and arylmethylamines with xanthate esters: a facile and unexpected synthesis of carbamothioates
por: Rajeev, Narasimhamurthy, et al.
Publicado: (2020)

Brusatol, a Nrf2 Inhibitor Targets STAT3 Signaling Cascade in Head and Neck Squamous Cell Carcinoma
por: Lee, Jong Hyun, et al.
Publicado: (2019)

NETosis and lack of DNase activity are key factors in Echis carinatus venom-induced tissue destruction
por: Katkar, Gajanan D., et al.
Publicado: (2016)

Identification of Novel Class of Triazolo-Thiadiazoles as Potent Inhibitors of Human Heparanase and their Anticancer Activity
por: Baburajeev, C. P., et al.
Publicado: (2017)

Novel 1,3,4-oxadiazole Targets STAT3 Signaling to Induce Antitumor Effect in Lung Cancer
por: Malojirao, Vikas H., et al.
Publicado: (2020)

Targeting Heparanase in Cancer: Inhibition by Synthetic, Chemically Modified, and Natural Compounds
por: Mohan, Chakrabhavi Dhananjaya, et al.
Publicado: (2019)

Anti-cancer activity of novel dibenzo[b,f]azepine tethered isoxazoline derivatives
por: Sadashiva, Maralinganadoddi Panchegowda, et al.
Publicado: (2012)

Synthesis and Characterization of Novel 2-Amino-Chromene-Nitriles that Target Bcl-2 in Acute Myeloid Leukemia Cell Lines
por: Keerthy, Hosadurga K., et al.
Publicado: (2014)

Correction: A New Ibuprofen Derivative Inhibits Platelet Aggregation and ROS Mediated Platelet Apoptosis
Publicado: (2014)

A Nano-MgO and Ionic Liquid-Catalyzed ‘Green’ Synthesis Protocol for the Development of Adamantyl-Imidazolo-Thiadiazoles as Anti-Tuberculosis Agents Targeting Sterol 14α-Demethylase (CYP51)
por: Anusha, Sebastian, et al.
Publicado: (2015)

Novel 1,3,4-Oxadiazole Induces Anticancer Activity by Targeting NF-κB in Hepatocellular Carcinoma Cells
por: Mohan, Chakrabhavi Dhananjaya, et al.
Publicado: (2018)

The IκB Kinase Inhibitor ACHP Targets the STAT3 Signaling Pathway in Human Non-Small Cell Lung Carcinoma Cells
por: Lee, Jong Hyun, et al.
Publicado: (2019)

Anti-proliferative activity and characterization data on oxadiazole derivatives
por: Dukanya, et al.
Publicado: (2020)

Escaping mechanisms of ESKAPE pathogens from antibiotics and their targeting by natural compounds
por: Jadimurthy, Ragi, et al.
Publicado: (2022)

Identification of a novel 1,2 oxazine that can induce apoptosis by targeting NF-κB in hepatocellular carcinoma cells
por: Somu, Chaithanya, et al.
Publicado: (2020)

Investigation of NPB Analogs That Target Phosphorylation of BAD-Ser99 in Human Mammary Carcinoma Cells
por: Girimanchanaika, Swamy Savvemala, et al.
Publicado: (2021)

Platelet aggregation inducing activity of Ficus racemosa stem bark extracts
por: Ahmed, Faiyaz, et al.
Publicado: (2012)

Adding to platelet safety and life: Platelet additive solutions
por: Mathur, Ankit, et al.
Publicado: (2018)

Trisubstituted-Imidazoles Induce Apoptosis in Human Breast Cancer Cells by Targeting the Oncogenic PI3K/Akt/mTOR Signaling Pathway
por: Mohan, Chakrabhavi Dhananjaya, et al.
Publicado: (2016)

Breast Cancer Stem-Like Cells Are Inhibited by Diosgenin, a Steroidal Saponin, by the Attenuation of the Wnt β-Catenin Signaling via the Wnt Antagonist Secreted Frizzled Related Protein-4
por: Bhuvanalakshmi, G., et al.
Publicado: (2017)

Functions of Cationic Host Defense Peptides in Immunity
por: Hemshekhar, Mahadevappa, et al.
Publicado: (2016)

N-Substituted Pyrido-1,4-Oxazin-3-Ones Induce Apoptosis of Hepatocellular Carcinoma Cells by Targeting NF-κB Signaling Pathway
por: Mohan, Chakrabhavi Dhananjaya, et al.
Publicado: (2018)

Euphorbiasteroid Abrogates EGFR and Wnt/β-Catenin Signaling in Non-Small-Cell Lung Cancer Cells to Impart Anticancer Activity
por: Kim, Na Young, et al.
Publicado: (2022)

Novel Adamantanyl-Based Thiadiazolyl Pyrazoles Targeting EGFR in Triple-Negative Breast Cancer
por: Sebastian, Anusha, et al.
Publicado: (2016)

Brusatol suppresses STAT3-driven metastasis by downregulating epithelial-mesenchymal transition in hepatocellular carcinoma
por: Lee, Jong Hyun, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_r75fudlhe0nofhje3uc71eguh0