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Pregnancy outcomes in women with idiopathic thrombocytopenic purpura
Background: Idiopathic thrombocytopenic purpura (ITP) is a disease that commonly affects women of reproductive age and is associated with maternal and fetal complications. Objective: The aim of the present study was to report the perinatal outcome in pregnant women with ITP. Materials and Methods: T...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Research and Clinical Center for Infertility
2012
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4169689/ https://www.ncbi.nlm.nih.gov/pubmed/25246917 |
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author | Yassaee, Fakhrolmolouk Eskandari, Roghieh Amiri, Zohreh |
author_facet | Yassaee, Fakhrolmolouk Eskandari, Roghieh Amiri, Zohreh |
author_sort | Yassaee, Fakhrolmolouk |
collection | PubMed |
description | Background: Idiopathic thrombocytopenic purpura (ITP) is a disease that commonly affects women of reproductive age and is associated with maternal and fetal complications. Objective: The aim of the present study was to report the perinatal outcome in pregnant women with ITP. Materials and Methods: Twenty one pregnant women with ITP admitted in a teaching hospital in Tehran, from October 2008 to February 2010, were enrolled in this prospective historical cohort study; course and perinatal outcome of pregnancies were studied. Results: Seven (33.3%) cases had been diagnosed before pregnancy, while the other fourteen (66.7%) were diagnosed during pregnancy. During hospitalization, thirteen (62%) patients required treatment, eight (61.5%) of them with steroids, two (15.3%) received intravenous immunoglobulin (IVIG), and three (23%) were treated with steroids and IVIG. Three babies were delivered vaginally (14.3%), seventeen (81%) through cesarean section and one patient aborted her fetus. Nine mothers (42.9%) had platelet counts <50000/ml at the time of delivery; but postpartum hemorrhage occurred in 4 (19%) women and one women received platelet transfusion during cesarean section. Six (28.6%) women developed gestational diabetes. Pregnancy was complicated by preeclampsia in one woman and by abruptio placenta in another. One pregnancy terminated in intrauterine fetal death. Seventeen infants (89.5%) had normal platelet counts, and two (10.5%) had moderate thrombocytopenia. No infant showed signs of hemorrhage, but 2 neonates (10.5%) were diagnosed with intrauterine growth restriction. Conclusion: Rate of gestational diabetes in pregnant women with ITP is higher than the general population. Rate of gestinational diabetes is 3-5% and postpartum hemorrhage is 5-7% in general. Postpartum hemorrhage is common in these women. Severe thrombocytopenia and bleeding in the newborns are uncommon. |
format | Online Article Text |
id | pubmed-4169689 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Research and Clinical Center for Infertility |
record_format | MEDLINE/PubMed |
spelling | pubmed-41696892014-09-22 Pregnancy outcomes in women with idiopathic thrombocytopenic purpura Yassaee, Fakhrolmolouk Eskandari, Roghieh Amiri, Zohreh Iran J Reprod Med Short Communication Background: Idiopathic thrombocytopenic purpura (ITP) is a disease that commonly affects women of reproductive age and is associated with maternal and fetal complications. Objective: The aim of the present study was to report the perinatal outcome in pregnant women with ITP. Materials and Methods: Twenty one pregnant women with ITP admitted in a teaching hospital in Tehran, from October 2008 to February 2010, were enrolled in this prospective historical cohort study; course and perinatal outcome of pregnancies were studied. Results: Seven (33.3%) cases had been diagnosed before pregnancy, while the other fourteen (66.7%) were diagnosed during pregnancy. During hospitalization, thirteen (62%) patients required treatment, eight (61.5%) of them with steroids, two (15.3%) received intravenous immunoglobulin (IVIG), and three (23%) were treated with steroids and IVIG. Three babies were delivered vaginally (14.3%), seventeen (81%) through cesarean section and one patient aborted her fetus. Nine mothers (42.9%) had platelet counts <50000/ml at the time of delivery; but postpartum hemorrhage occurred in 4 (19%) women and one women received platelet transfusion during cesarean section. Six (28.6%) women developed gestational diabetes. Pregnancy was complicated by preeclampsia in one woman and by abruptio placenta in another. One pregnancy terminated in intrauterine fetal death. Seventeen infants (89.5%) had normal platelet counts, and two (10.5%) had moderate thrombocytopenia. No infant showed signs of hemorrhage, but 2 neonates (10.5%) were diagnosed with intrauterine growth restriction. Conclusion: Rate of gestational diabetes in pregnant women with ITP is higher than the general population. Rate of gestinational diabetes is 3-5% and postpartum hemorrhage is 5-7% in general. Postpartum hemorrhage is common in these women. Severe thrombocytopenia and bleeding in the newborns are uncommon. Research and Clinical Center for Infertility 2012-09 /pmc/articles/PMC4169689/ /pubmed/25246917 Text en This is an Open Access article distributed under the terms of the Creative Commons Attribution License, (http://creativecommons.org/licenses/by/3.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Short Communication Yassaee, Fakhrolmolouk Eskandari, Roghieh Amiri, Zohreh Pregnancy outcomes in women with idiopathic thrombocytopenic purpura |
title | Pregnancy outcomes in women with idiopathic thrombocytopenic purpura |
title_full | Pregnancy outcomes in women with idiopathic thrombocytopenic purpura |
title_fullStr | Pregnancy outcomes in women with idiopathic thrombocytopenic purpura |
title_full_unstemmed | Pregnancy outcomes in women with idiopathic thrombocytopenic purpura |
title_short | Pregnancy outcomes in women with idiopathic thrombocytopenic purpura |
title_sort | pregnancy outcomes in women with idiopathic thrombocytopenic purpura |
topic | Short Communication |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4169689/ https://www.ncbi.nlm.nih.gov/pubmed/25246917 |
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