Cargando…
Meta-Analysis: Hoarding Symptoms Associated with Poor Treatment Outcome in Obsessive-Compulsive Disorder
DSM-5 recognizes Hoarding Disorder as distinct from Obsessive-Compulsive Disorder (OCD), codifying a new consensus. Hoarding Disorder was previously classified as a symptom of OCD and patients received treatments designed for OCD. We conducted a meta-analysis to determine whether OCD patients with h...
Autores principales: | , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2014
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4169729/ https://www.ncbi.nlm.nih.gov/pubmed/24912494 http://dx.doi.org/10.1038/mp.2014.50 |
_version_ | 1782335757943308288 |
---|---|
author | Bloch, Michael H. Bartley, Christine A. Zipperer, Lara Jakubovski, Ewgeni Landeros-Weisenberger, Angeli Pittenger, Christopher Leckman, James F. |
author_facet | Bloch, Michael H. Bartley, Christine A. Zipperer, Lara Jakubovski, Ewgeni Landeros-Weisenberger, Angeli Pittenger, Christopher Leckman, James F. |
author_sort | Bloch, Michael H. |
collection | PubMed |
description | DSM-5 recognizes Hoarding Disorder as distinct from Obsessive-Compulsive Disorder (OCD), codifying a new consensus. Hoarding Disorder was previously classified as a symptom of OCD and patients received treatments designed for OCD. We conducted a meta-analysis to determine whether OCD patients with hoarding symptoms responded differently to traditional OCD treatments than OCD patients without hoarding symptoms. An electronic search was conducted for eligible studies in PubMed. A trial was eligible for inclusion if it was (1) a randomized controlled trial, cohort or case-control study; (2) compared treatment response between OCD patients with and without hoarding symptoms, or examined response to treatment between OCD symptom dimensions (which typically include hoarding) and (3) examined treatment response to pharmacotherapy, behavioral therapy, or their combination. Our primary outcome was differential treatment response between OCD patients with and without hoarding, expressed as an odds ratio. Twenty-one studies involving 3039 total participants including 304 with hoarding symptoms were included. Patients with OCD and hoarding symptoms were significantly less likely to respond to traditional OCD treatments than OCD patients without hoarding symptoms (OR=0.50 (95%CI: 0.42–0.60), z=−7.5, p<0.0001). This finding was consistent across treatment modalities. OCD patients with hoarding symptoms represent a population in need of further treatment research. OCD patients with hoarding symptoms may benefit more from interventions specifically targeting their hoarding symptoms. |
format | Online Article Text |
id | pubmed-4169729 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
record_format | MEDLINE/PubMed |
spelling | pubmed-41697292015-03-01 Meta-Analysis: Hoarding Symptoms Associated with Poor Treatment Outcome in Obsessive-Compulsive Disorder Bloch, Michael H. Bartley, Christine A. Zipperer, Lara Jakubovski, Ewgeni Landeros-Weisenberger, Angeli Pittenger, Christopher Leckman, James F. Mol Psychiatry Article DSM-5 recognizes Hoarding Disorder as distinct from Obsessive-Compulsive Disorder (OCD), codifying a new consensus. Hoarding Disorder was previously classified as a symptom of OCD and patients received treatments designed for OCD. We conducted a meta-analysis to determine whether OCD patients with hoarding symptoms responded differently to traditional OCD treatments than OCD patients without hoarding symptoms. An electronic search was conducted for eligible studies in PubMed. A trial was eligible for inclusion if it was (1) a randomized controlled trial, cohort or case-control study; (2) compared treatment response between OCD patients with and without hoarding symptoms, or examined response to treatment between OCD symptom dimensions (which typically include hoarding) and (3) examined treatment response to pharmacotherapy, behavioral therapy, or their combination. Our primary outcome was differential treatment response between OCD patients with and without hoarding, expressed as an odds ratio. Twenty-one studies involving 3039 total participants including 304 with hoarding symptoms were included. Patients with OCD and hoarding symptoms were significantly less likely to respond to traditional OCD treatments than OCD patients without hoarding symptoms (OR=0.50 (95%CI: 0.42–0.60), z=−7.5, p<0.0001). This finding was consistent across treatment modalities. OCD patients with hoarding symptoms represent a population in need of further treatment research. OCD patients with hoarding symptoms may benefit more from interventions specifically targeting their hoarding symptoms. 2014-06-10 2014-09 /pmc/articles/PMC4169729/ /pubmed/24912494 http://dx.doi.org/10.1038/mp.2014.50 Text en http://www.nature.com/authors/editorial_policies/license.html#terms Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use:http://www.nature.com/authors/editorial_policies/license.html#terms |
spellingShingle | Article Bloch, Michael H. Bartley, Christine A. Zipperer, Lara Jakubovski, Ewgeni Landeros-Weisenberger, Angeli Pittenger, Christopher Leckman, James F. Meta-Analysis: Hoarding Symptoms Associated with Poor Treatment Outcome in Obsessive-Compulsive Disorder |
title | Meta-Analysis: Hoarding Symptoms Associated with Poor Treatment Outcome in Obsessive-Compulsive Disorder |
title_full | Meta-Analysis: Hoarding Symptoms Associated with Poor Treatment Outcome in Obsessive-Compulsive Disorder |
title_fullStr | Meta-Analysis: Hoarding Symptoms Associated with Poor Treatment Outcome in Obsessive-Compulsive Disorder |
title_full_unstemmed | Meta-Analysis: Hoarding Symptoms Associated with Poor Treatment Outcome in Obsessive-Compulsive Disorder |
title_short | Meta-Analysis: Hoarding Symptoms Associated with Poor Treatment Outcome in Obsessive-Compulsive Disorder |
title_sort | meta-analysis: hoarding symptoms associated with poor treatment outcome in obsessive-compulsive disorder |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4169729/ https://www.ncbi.nlm.nih.gov/pubmed/24912494 http://dx.doi.org/10.1038/mp.2014.50 |
work_keys_str_mv | AT blochmichaelh metaanalysishoardingsymptomsassociatedwithpoortreatmentoutcomeinobsessivecompulsivedisorder AT bartleychristinea metaanalysishoardingsymptomsassociatedwithpoortreatmentoutcomeinobsessivecompulsivedisorder AT zippererlara metaanalysishoardingsymptomsassociatedwithpoortreatmentoutcomeinobsessivecompulsivedisorder AT jakubovskiewgeni metaanalysishoardingsymptomsassociatedwithpoortreatmentoutcomeinobsessivecompulsivedisorder AT landerosweisenbergerangeli metaanalysishoardingsymptomsassociatedwithpoortreatmentoutcomeinobsessivecompulsivedisorder AT pittengerchristopher metaanalysishoardingsymptomsassociatedwithpoortreatmentoutcomeinobsessivecompulsivedisorder AT leckmanjamesf metaanalysishoardingsymptomsassociatedwithpoortreatmentoutcomeinobsessivecompulsivedisorder |