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Recurrent hypoglycaemia in type-1 diabetes mellitus may unravel the association with Addison’s disease: a case report
BACKGROUND: Primary adrenocortical insufficiency or Addison’s disease is caused by a progressive destruction of the adrenal cortex, resulting into a reduction of glucocorticoids, mineralocorticoids, and androgens. Autoimmune Addison’s disease is the most common etiological form, accounting for about...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4169830/ https://www.ncbi.nlm.nih.gov/pubmed/25214204 http://dx.doi.org/10.1186/1756-0500-7-634 |
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author | Passanisi, Stefano Timpanaro, Tiziana Lo Presti, Donatella Caruso-Nicoletti, Manuela |
author_facet | Passanisi, Stefano Timpanaro, Tiziana Lo Presti, Donatella Caruso-Nicoletti, Manuela |
author_sort | Passanisi, Stefano |
collection | PubMed |
description | BACKGROUND: Primary adrenocortical insufficiency or Addison’s disease is caused by a progressive destruction of the adrenal cortex, resulting into a reduction of glucocorticoids, mineralocorticoids, and androgens. Autoimmune Addison’s disease is the most common etiological form, accounting for about 80% of all cases. CASE PRESENTATION: We describe the case of a 16-year-old Caucasian boy affected by type-1 diabetes mellitus and autoimmune thyroiditis, who experienced recurrent hypoglycaemia as presenting symptom of Addison’s disease. CONCLUSIONS: Hypoglycaemia is not a common presenting feature of Addison’s disease, both in patients with type-1 diabetes mellitus and in non-diabetic patients. However, hypoglycaemia may occur in association with primary and secondary glucocorticoid deficiency as a result of an enhanced insulin sensitivity. Hypoglycaemia is the most common acute complication of insulin therapy in patients with type-1 diabetes mellitus. Addison’s disease has been described in approximately 0.5% of patients with type-1 diabetes mellitus, being more frequent in females and occurring in middle-aged patients. An association among type-1 diabetes mellitus, autoimmune thyroiditis, and Addison’s disease is found in the “Schmidt’s syndrome”, a rare disorder that may occur in the paediatric age. Our case suggests that the presence of Addison’s disease should be taken into consideration in patients with type-1 diabetes mellitus and frequent episodes of hypoglycaemia. We wish to highlight that there are no specific indications to screen for the association between Addison’s disease and type-1 diabetes mellitus, although an early diagnosis of Addison’s disease in diabetic patients would prevent the morbidity and potential mortality of this association. |
format | Online Article Text |
id | pubmed-4169830 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-41698302014-09-22 Recurrent hypoglycaemia in type-1 diabetes mellitus may unravel the association with Addison’s disease: a case report Passanisi, Stefano Timpanaro, Tiziana Lo Presti, Donatella Caruso-Nicoletti, Manuela BMC Res Notes Case Report BACKGROUND: Primary adrenocortical insufficiency or Addison’s disease is caused by a progressive destruction of the adrenal cortex, resulting into a reduction of glucocorticoids, mineralocorticoids, and androgens. Autoimmune Addison’s disease is the most common etiological form, accounting for about 80% of all cases. CASE PRESENTATION: We describe the case of a 16-year-old Caucasian boy affected by type-1 diabetes mellitus and autoimmune thyroiditis, who experienced recurrent hypoglycaemia as presenting symptom of Addison’s disease. CONCLUSIONS: Hypoglycaemia is not a common presenting feature of Addison’s disease, both in patients with type-1 diabetes mellitus and in non-diabetic patients. However, hypoglycaemia may occur in association with primary and secondary glucocorticoid deficiency as a result of an enhanced insulin sensitivity. Hypoglycaemia is the most common acute complication of insulin therapy in patients with type-1 diabetes mellitus. Addison’s disease has been described in approximately 0.5% of patients with type-1 diabetes mellitus, being more frequent in females and occurring in middle-aged patients. An association among type-1 diabetes mellitus, autoimmune thyroiditis, and Addison’s disease is found in the “Schmidt’s syndrome”, a rare disorder that may occur in the paediatric age. Our case suggests that the presence of Addison’s disease should be taken into consideration in patients with type-1 diabetes mellitus and frequent episodes of hypoglycaemia. We wish to highlight that there are no specific indications to screen for the association between Addison’s disease and type-1 diabetes mellitus, although an early diagnosis of Addison’s disease in diabetic patients would prevent the morbidity and potential mortality of this association. BioMed Central 2014-09-12 /pmc/articles/PMC4169830/ /pubmed/25214204 http://dx.doi.org/10.1186/1756-0500-7-634 Text en © Passanisi et al.; licensee BioMed Central Ltd. 2014 This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Case Report Passanisi, Stefano Timpanaro, Tiziana Lo Presti, Donatella Caruso-Nicoletti, Manuela Recurrent hypoglycaemia in type-1 diabetes mellitus may unravel the association with Addison’s disease: a case report |
title | Recurrent hypoglycaemia in type-1 diabetes mellitus may unravel the association with Addison’s disease: a case report |
title_full | Recurrent hypoglycaemia in type-1 diabetes mellitus may unravel the association with Addison’s disease: a case report |
title_fullStr | Recurrent hypoglycaemia in type-1 diabetes mellitus may unravel the association with Addison’s disease: a case report |
title_full_unstemmed | Recurrent hypoglycaemia in type-1 diabetes mellitus may unravel the association with Addison’s disease: a case report |
title_short | Recurrent hypoglycaemia in type-1 diabetes mellitus may unravel the association with Addison’s disease: a case report |
title_sort | recurrent hypoglycaemia in type-1 diabetes mellitus may unravel the association with addison’s disease: a case report |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4169830/ https://www.ncbi.nlm.nih.gov/pubmed/25214204 http://dx.doi.org/10.1186/1756-0500-7-634 |
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