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Effect of vitamin D(3) on mild to moderate persistent asthmatic patients: A randomized controlled pilot study
BACKGROUND: Asthma is a common chronic inflammatory disease of the bronchial airways. Well defined treatment options for asthma are very few. The role of vitamin D(3) on asthma is still baffling. Aim: We have examined the effect of vitamin D(3) supplementation in mild to moderate persistent asthma p...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Medknow Publications & Media Pvt Ltd
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4170534/ https://www.ncbi.nlm.nih.gov/pubmed/25276626 http://dx.doi.org/10.4103/2229-3485.140556 |
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author | Nageswari, A. D. Rajanandh, M. G. Priyanka, R. Kamala Rajasekhar, P. |
author_facet | Nageswari, A. D. Rajanandh, M. G. Priyanka, R. Kamala Rajasekhar, P. |
author_sort | Nageswari, A. D. |
collection | PubMed |
description | BACKGROUND: Asthma is a common chronic inflammatory disease of the bronchial airways. Well defined treatment options for asthma are very few. The role of vitamin D(3) on asthma is still baffling. Aim: We have examined the effect of vitamin D(3) supplementation in mild to moderate persistent asthma patients. MATERIALS AND METHODS: We conducted an open labeled, randomized comparative trial in 48 asthma patients. The study duration was about 90 days. The study had a run-in-period of 2 weeks. At the end of run-in-period, patients were divided into two groups: Usual care group (n = 31) patients received budesonide and formoterol and intervention care group (n = 32) patients received vitamin D(3) supplementation along with their regular medicine. RESULTS: The primary outcome of the study was to measure the improvement in forced expiratory volume in 1 second (FEV(1)). Patients in both groups had a significant improvement in FEV(1) at the end of the study. The mean difference in percentage predicted FEV(1) in usual care and intervention care group was 4.95 and 7.07 respectively. CONCLUSION: The study concluded that adjunctive therapy of vitamin D(3) is effective in asthma patients. The present study will be an evidence based report; however, future studies are warranted in longer duration of time to substantiate the present findings. |
format | Online Article Text |
id | pubmed-4170534 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Medknow Publications & Media Pvt Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-41705342014-10-01 Effect of vitamin D(3) on mild to moderate persistent asthmatic patients: A randomized controlled pilot study Nageswari, A. D. Rajanandh, M. G. Priyanka, R. Kamala Rajasekhar, P. Perspect Clin Res Original Article BACKGROUND: Asthma is a common chronic inflammatory disease of the bronchial airways. Well defined treatment options for asthma are very few. The role of vitamin D(3) on asthma is still baffling. Aim: We have examined the effect of vitamin D(3) supplementation in mild to moderate persistent asthma patients. MATERIALS AND METHODS: We conducted an open labeled, randomized comparative trial in 48 asthma patients. The study duration was about 90 days. The study had a run-in-period of 2 weeks. At the end of run-in-period, patients were divided into two groups: Usual care group (n = 31) patients received budesonide and formoterol and intervention care group (n = 32) patients received vitamin D(3) supplementation along with their regular medicine. RESULTS: The primary outcome of the study was to measure the improvement in forced expiratory volume in 1 second (FEV(1)). Patients in both groups had a significant improvement in FEV(1) at the end of the study. The mean difference in percentage predicted FEV(1) in usual care and intervention care group was 4.95 and 7.07 respectively. CONCLUSION: The study concluded that adjunctive therapy of vitamin D(3) is effective in asthma patients. The present study will be an evidence based report; however, future studies are warranted in longer duration of time to substantiate the present findings. Medknow Publications & Media Pvt Ltd 2014 /pmc/articles/PMC4170534/ /pubmed/25276626 http://dx.doi.org/10.4103/2229-3485.140556 Text en Copyright: © Perspectives in Clinical Research http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Nageswari, A. D. Rajanandh, M. G. Priyanka, R. Kamala Rajasekhar, P. Effect of vitamin D(3) on mild to moderate persistent asthmatic patients: A randomized controlled pilot study |
title | Effect of vitamin D(3) on mild to moderate persistent asthmatic patients: A randomized controlled pilot study |
title_full | Effect of vitamin D(3) on mild to moderate persistent asthmatic patients: A randomized controlled pilot study |
title_fullStr | Effect of vitamin D(3) on mild to moderate persistent asthmatic patients: A randomized controlled pilot study |
title_full_unstemmed | Effect of vitamin D(3) on mild to moderate persistent asthmatic patients: A randomized controlled pilot study |
title_short | Effect of vitamin D(3) on mild to moderate persistent asthmatic patients: A randomized controlled pilot study |
title_sort | effect of vitamin d(3) on mild to moderate persistent asthmatic patients: a randomized controlled pilot study |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4170534/ https://www.ncbi.nlm.nih.gov/pubmed/25276626 http://dx.doi.org/10.4103/2229-3485.140556 |
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