Acute High Dose Lithium-Induced Exacerbation of Obsessive Compulsive Symptoms

Obsessive compulsive disorder (OCD) is a chronic neuropsychiatric disorder whose pathophysiology is linked to serotonergic dysfunction. More recently, the role of glutamate has also been posited. Lithium is used as an adjunctive for the treatment of OCD which is found to enhance serotonergic transmi...

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Detalles Bibliográficos
Autores principales: Umesh, Shreekantiah, Sinha, Vinod Kumar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2014
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4170567/
https://www.ncbi.nlm.nih.gov/pubmed/25253935
http://dx.doi.org/10.4103/0971-6580.139816
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author Umesh, Shreekantiah
Sinha, Vinod Kumar
author_facet Umesh, Shreekantiah
Sinha, Vinod Kumar
author_sort Umesh, Shreekantiah
collection PubMed
description Obsessive compulsive disorder (OCD) is a chronic neuropsychiatric disorder whose pathophysiology is linked to serotonergic dysfunction. More recently, the role of glutamate has also been posited. Lithium is used as an adjunctive for the treatment of OCD which is found to enhance serotonergic transmission. We present a case of OCD who was on stable dose of sertraline developed exacerbation of obsessive compulsive symptoms with acute high dose of lithium but improved after dose reduction.
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spelling pubmed-41705672014-09-24 Acute High Dose Lithium-Induced Exacerbation of Obsessive Compulsive Symptoms Umesh, Shreekantiah Sinha, Vinod Kumar Toxicol Int Case Report Obsessive compulsive disorder (OCD) is a chronic neuropsychiatric disorder whose pathophysiology is linked to serotonergic dysfunction. More recently, the role of glutamate has also been posited. Lithium is used as an adjunctive for the treatment of OCD which is found to enhance serotonergic transmission. We present a case of OCD who was on stable dose of sertraline developed exacerbation of obsessive compulsive symptoms with acute high dose of lithium but improved after dose reduction. Medknow Publications & Media Pvt Ltd 2014 /pmc/articles/PMC4170567/ /pubmed/25253935 http://dx.doi.org/10.4103/0971-6580.139816 Text en Copyright: © Toxicology International http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Umesh, Shreekantiah
Sinha, Vinod Kumar
Acute High Dose Lithium-Induced Exacerbation of Obsessive Compulsive Symptoms
title Acute High Dose Lithium-Induced Exacerbation of Obsessive Compulsive Symptoms
title_full Acute High Dose Lithium-Induced Exacerbation of Obsessive Compulsive Symptoms
title_fullStr Acute High Dose Lithium-Induced Exacerbation of Obsessive Compulsive Symptoms
title_full_unstemmed Acute High Dose Lithium-Induced Exacerbation of Obsessive Compulsive Symptoms
title_short Acute High Dose Lithium-Induced Exacerbation of Obsessive Compulsive Symptoms
title_sort acute high dose lithium-induced exacerbation of obsessive compulsive symptoms
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4170567/
https://www.ncbi.nlm.nih.gov/pubmed/25253935
http://dx.doi.org/10.4103/0971-6580.139816
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AT sinhavinodkumar acutehighdoselithiuminducedexacerbationofobsessivecompulsivesymptoms

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