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hMLH1 promoter methylation and BRAF mutations in high-frequency microsatellite instability colorectal cancers not fulfilling the revised Bethesda guidelines

PURPOSE: Sporadic colorectal cancers with high-frequency microsatellite instability (MSI-H) are related to hypermethylation of mismatch repair (MMR) genes and a higher frequency of BRAF mutations than Lynch syndrome. We estimated the feasibility of hereditary colorectal cancer based on hMLH1 methyla...

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Detalles Bibliográficos
Autores principales:	Kim, Sang Jin, Kim, Hyoung Ran, Kim, Seok Hyung, Han, Ji Hye, Cho, Yong Beom, Yun, Seong Hyeon, Lee, Woo Yong, Kim, Hee Cheol
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Korean Surgical Society 2014
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4170578/ https://www.ncbi.nlm.nih.gov/pubmed/25247165 http://dx.doi.org/10.4174/astr.2014.87.3.123

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