FAS/FASL are dysregulated in chordoma and their loss-of-function impairs zebrafish notochord formation

Chordoma is a rare malignant tumor that recapitulates the notochord phenotype and is thought to derive from notochord remnants not correctly regressed during development. Apoptosis is necessary for the proper notochord development in vertebrates, and the apoptotic pathway mediated by Fas and Fasl ha...

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Detalles Bibliográficos
Autores principales: Ferrari, Luca, Pistocchi, Anna, Libera, Laura, Boari, Nicola, Mortini, Pietro, Bellipanni, Gianfranco, Giordano, Antonio, Cotelli, Franco, Riva, Paola
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2014
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4170636/
https://www.ncbi.nlm.nih.gov/pubmed/25071022

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