Superoxide Dismutase 1 Loss Disturbs Intracellular Redox Signaling, Resulting in Global Age-Related Pathological Changes

Aging is characterized by increased oxidative stress, chronic inflammation, and organ dysfunction, which occur in a progressive and irreversible manner. Superoxide dismutase (SOD) serves as a major antioxidant and neutralizes superoxide radicals throughout the body. In vivo studies have demonstrated...

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Autores principales: Watanabe, Kenji, Shibuya, Shuichi, Ozawa, Yusuke, Nojiri, Hidetoshi, Izuo, Naotaka, Yokote, Koutaro, Shimizu, Takahiko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2014
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4170698/
https://www.ncbi.nlm.nih.gov/pubmed/25276767
http://dx.doi.org/10.1155/2014/140165
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author Watanabe, Kenji
Shibuya, Shuichi
Ozawa, Yusuke
Nojiri, Hidetoshi
Izuo, Naotaka
Yokote, Koutaro
Shimizu, Takahiko
author_facet Watanabe, Kenji
Shibuya, Shuichi
Ozawa, Yusuke
Nojiri, Hidetoshi
Izuo, Naotaka
Yokote, Koutaro
Shimizu, Takahiko
author_sort Watanabe, Kenji
collection PubMed
description Aging is characterized by increased oxidative stress, chronic inflammation, and organ dysfunction, which occur in a progressive and irreversible manner. Superoxide dismutase (SOD) serves as a major antioxidant and neutralizes superoxide radicals throughout the body. In vivo studies have demonstrated that copper/zinc superoxide dismutase-deficient (Sod1(−/−)) mice show various aging-like pathologies, accompanied by augmentation of oxidative damage in organs. We found that antioxidant treatment significantly attenuated the age-related tissue changes and oxidative damage-associated p53 upregulation in Sod1(−/−) mice. This review will focus on various age-related pathologies caused by the loss of Sod1 and will discuss the molecular mechanisms underlying the pathogenesis in Sod1(−/−) mice.
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spelling pubmed-41706982014-09-28 Superoxide Dismutase 1 Loss Disturbs Intracellular Redox Signaling, Resulting in Global Age-Related Pathological Changes Watanabe, Kenji Shibuya, Shuichi Ozawa, Yusuke Nojiri, Hidetoshi Izuo, Naotaka Yokote, Koutaro Shimizu, Takahiko Biomed Res Int Review Article Aging is characterized by increased oxidative stress, chronic inflammation, and organ dysfunction, which occur in a progressive and irreversible manner. Superoxide dismutase (SOD) serves as a major antioxidant and neutralizes superoxide radicals throughout the body. In vivo studies have demonstrated that copper/zinc superoxide dismutase-deficient (Sod1(−/−)) mice show various aging-like pathologies, accompanied by augmentation of oxidative damage in organs. We found that antioxidant treatment significantly attenuated the age-related tissue changes and oxidative damage-associated p53 upregulation in Sod1(−/−) mice. This review will focus on various age-related pathologies caused by the loss of Sod1 and will discuss the molecular mechanisms underlying the pathogenesis in Sod1(−/−) mice. Hindawi Publishing Corporation 2014 2014-09-08 /pmc/articles/PMC4170698/ /pubmed/25276767 http://dx.doi.org/10.1155/2014/140165 Text en Copyright © 2014 Kenji Watanabe et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Watanabe, Kenji
Shibuya, Shuichi
Ozawa, Yusuke
Nojiri, Hidetoshi
Izuo, Naotaka
Yokote, Koutaro
Shimizu, Takahiko
Superoxide Dismutase 1 Loss Disturbs Intracellular Redox Signaling, Resulting in Global Age-Related Pathological Changes
title Superoxide Dismutase 1 Loss Disturbs Intracellular Redox Signaling, Resulting in Global Age-Related Pathological Changes
title_full Superoxide Dismutase 1 Loss Disturbs Intracellular Redox Signaling, Resulting in Global Age-Related Pathological Changes
title_fullStr Superoxide Dismutase 1 Loss Disturbs Intracellular Redox Signaling, Resulting in Global Age-Related Pathological Changes
title_full_unstemmed Superoxide Dismutase 1 Loss Disturbs Intracellular Redox Signaling, Resulting in Global Age-Related Pathological Changes
title_short Superoxide Dismutase 1 Loss Disturbs Intracellular Redox Signaling, Resulting in Global Age-Related Pathological Changes
title_sort superoxide dismutase 1 loss disturbs intracellular redox signaling, resulting in global age-related pathological changes
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4170698/
https://www.ncbi.nlm.nih.gov/pubmed/25276767
http://dx.doi.org/10.1155/2014/140165
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