Cargando…

Lung Cancer Stem Cell Lose Their Stemness Default State after Exposure to Microgravity

Microgravity influences cell differentiation by modifying the morphogenetic field in which stem cells are embedded. Preliminary data showed indeed that stem cells are committed to selective differentiation when exposed to real or simulated microgravity. Our study provides evidence that a similar eve...

Descripción completa

Detalles Bibliográficos
Autores principales:	Pisanu, Maria Elena, Noto, Alessia, De Vitis, Claudia, Masiello, Maria Grazia, Coluccia, Pierpaolo, Proietti, Sara, Giovagnoli, Maria Rosaria, Ricci, Alberto, Giarnieri, Enrico, Cucina, Alessandra, Ciliberto, Gennaro, Bizzarri, Mariano, Mancini, Rita
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi Publishing Corporation 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4170742/ https://www.ncbi.nlm.nih.gov/pubmed/25276790 http://dx.doi.org/10.1155/2014/470253

Ejemplares similares

Phenotypic Switch Induced by Simulated Microgravity on MDA-MB-231 Breast Cancer Cells
por: Masiello, Maria Grazia, et al.
Publicado: (2014)

Simulated microgravity triggers epithelial mesenchymal transition in human keratinocytes
por: Ranieri, Danilo, et al.
Publicado: (2017)

Survival Pathways Are Differently Affected by Microgravity in Normal and Cancerous Breast Cells
por: Monti, Noemi, et al.
Publicado: (2021)

Microgravity influences circadian clock oscillation in human keratinocytes
por: Ranieri, Danilo, et al.
Publicado: (2015)

Combination therapy with anti-ErbB3 monoclonal antibodies and EGFR TKIs potently inhibits Non-small Cell Lung Cancer
por: Noto, Alessia, et al.
Publicado: (2013)

Phenotypic transitions enacted by simulated microgravity do not alter coherence in gene transcription profile
por: Po, Agnese, et al.
Publicado: (2019)

Antioxidant Strategy to Prevent Simulated Microgravity-Induced Effects on Bone Osteoblasts
por: Morabito, Caterina, et al.
Publicado: (2020)

Human lung adenocarcinoma cell cultures derived from malignant pleural effusions as model system to predict patients chemosensitivity
por: Roscilli, Giuseppe, et al.
Publicado: (2016)

Combination of antibodies directed against different ErbB3 surface epitopes prevents the establishment of resistance to BRAF/MEK inhibitors in melanoma
por: Fattore, Luigi, et al.
Publicado: (2015)

Activation of the ErbB3-AKT axis promotes melanoma cell survival and proliferation in response to RAF/MEK inhibition
por: Fattore, Luigi, et al.
Publicado: (2014)

Activation of an early feedback survival loop involving phospho-ErbB3 is a general response of melanoma cells to RAF/MEK inhibition and is abrogated by anti-ErbB3 antibodies
por: Fattore, Luigi, et al.
Publicado: (2013)

Towards the integration of digital cytology in the tablet technologies
por: Giansanti, Daniele, et al.
Publicado: (2013)

Stearoyl-CoA desaturase-1 is a key factor for lung cancer-initiating cells
por: Noto, A, et al.
Publicado: (2013)

Cytoskeleton Modifications and Autophagy Induction in TCam-2 Seminoma Cells Exposed to Simulated Microgravity
por: Ferranti, Francesca, et al.
Publicado: (2014)

Spheres Derived from Lung Adenocarcinoma Pleural Effusions: Molecular Characterization and Tumor Engraftment
por: Mancini, Rita, et al.
Publicado: (2011)

Microenvironment Promotes Tumor Cell Reprogramming in Human Breast Cancer Cell Lines
por: D’Anselmi, Fabrizio, et al.
Publicado: (2013)

Alpha-Lipoic Acid Downregulates IL-1β and IL-6 by DNA Hypermethylation in SK-N-BE Neuroblastoma Cells
por: Dinicola, Simona, et al.
Publicado: (2017)

Inhibition of Stearoyl-CoA desaturase 1 reverts BRAF and MEK inhibition-induced selection of cancer stem cells in BRAF-mutated melanoma
por: Pisanu, Maria Elena, et al.
Publicado: (2018)

Effects of Simulated Microgravity In Vitro on Human Metaphase II Oocytes: An Electron Microscopy-Based Study
por: Miglietta, Selenia, et al.
Publicado: (2023)

CytoMatrix for a reliable and simple characterization of lung cancer stem cells from malignant pleural effusions
por: Bruschini, Sara, et al.
Publicado: (2019)

c-Src Recruitment is Involved in c-MET-Mediated Malignant Behaviour of NT2D1 Non-Seminoma Cells
por: Leonetti, Erica, et al.
Publicado: (2019)

Ferritin heavy chain is a negative regulator of ovarian cancer stem cell expansion and epithelial to mesenchymal transition
por: Lobello, Nadia, et al.
Publicado: (2016)

Physiological Responses of Jurkat Lymphocytes to Simulated Microgravity Conditions
por: Morabito, Caterina, et al.
Publicado: (2019)

How Microgravity Affects the Biology of Living Systems
por: Bizzarri, Mariano, et al.
Publicado: (2015)

Tumor and the Microenvironment: A Chance to Reframe the Paradigm of Carcinogenesis?
por: Bizzarri, Mariano, et al.
Publicado: (2014)

Cancer Stem Cells and the Slow Cycling Phenotype: How to Cut the Gordian Knot Driving Resistance to Therapy in Melanoma
por: Fattore, Luigi, et al.
Publicado: (2020)

Microgravity Modifies the Phenotype of Fibroblast and Promotes Remodeling of the Fibroblast–Keratinocyte Interaction in a 3D Co-Culture Model
por: Fedeli, Valeria, et al.
Publicado: (2022)

B4GALT1 Is a New Candidate to Maintain the Stemness of Lung Cancer Stem Cells
por: De Vitis, Claudia, et al.
Publicado: (2019)

Effects of Simulated Microgravity on Embryonic Stem Cells
por: Wang, Yulan, et al.
Publicado: (2011)

On the connections between cancer stem cells and EMT
por: Cioce, Mario, et al.
Publicado: (2012)

SCD1, autophagy and cancer: implications for therapy
por: Ascenzi, Francesca, et al.
Publicado: (2021)

The effects of microgravity on differentiation and cell growth in stem cells and cancer stem cells
por: Grimm, Daniela, et al.
Publicado: (2020)

Broad Spectrum Anticancer Activity of Myo-Inositol and Inositol Hexakisphosphate
por: Bizzarri, Mariano, et al.
Publicado: (2016)

We Don’t Have to Lose STEM Students to Business
por: Wernick, Naomi L. B., et al.
Publicado: (2020)

Why stem/progenitor cells lose their regenerative potential
por: Picerno, Angela, et al.
Publicado: (2021)

Simulated microgravity promotes the formation of tridimensional cultures and stimulates pluripotency and a glycolytic metabolism in human hepatic and biliary tree stem/progenitor cells
por: Costantini, Daniele, et al.
Publicado: (2019)

Antiproliferative and Apoptotic Effects Triggered by Grape Seed Extract (GSE) versus Epigallocatechin and Procyanidins on Colon Cancer Cell Lines
por: Dinicola, Simona, et al.
Publicado: (2012)

LIF-Free Embryonic Stem Cell Culture in Simulated Microgravity
por: Kawahara, Yumi, et al.
Publicado: (2009)

Microgravity Reduces the Differentiation and Regenerative Potential of Embryonic Stem Cells
por: Blaber, Elizabeth A., et al.
Publicado: (2015)

Coculture of meniscus cells and mesenchymal stem cells in simulated microgravity
por: Weiss, William M., et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_che00fo5q77r2664j45quj7tja