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Usefulness of Magnetic Resonance Imaging as a Prognostic Variable in Myelodysplastic Syndromes
BACKGROUND: Myelodysplastic syndromes are clonal disorders of stem cells, characterized by heterogeneous clinical presentation. Hematopoiesis is ineffective, characterized by abnormal differentiation, maturation and survival of hematopoietic cells. MATERIAL/METHODS: The examinations were conducted i...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
International Scientific Literature, Inc.
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4170840/ https://www.ncbi.nlm.nih.gov/pubmed/25217620 http://dx.doi.org/10.12659/MSM.890978 |
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author | Ziółko, Ewa Kwiatkowska-Pamuła, Anna Adamczyk, Tomasz Walecki, Jerzy Muc-Wierzgoń, Małgorzata |
author_facet | Ziółko, Ewa Kwiatkowska-Pamuła, Anna Adamczyk, Tomasz Walecki, Jerzy Muc-Wierzgoń, Małgorzata |
author_sort | Ziółko, Ewa |
collection | PubMed |
description | BACKGROUND: Myelodysplastic syndromes are clonal disorders of stem cells, characterized by heterogeneous clinical presentation. Hematopoiesis is ineffective, characterized by abnormal differentiation, maturation and survival of hematopoietic cells. MATERIAL/METHODS: The examinations were conducted in the Hematology Ward and the Internal Medicine Ward of the Specialist Hospital No. 1 in Bytom in the years 2006–2011. The study group included 53 patients with diagnosed myelodysplastic syndrome. The results of magnetic resonance imaging (MRI) of the spine were obtained from the medical documentation of patients. RESULTS: In the group of patients diagnosed with RT (refractory thrombocytopenia) and in the group diagnosed with RA (refractory anemia), 100% of lumbar spine images in T1- and T2-weighted sequences assessed together showed increased signal intensity. In patients diagnosed with RAEB (refractory anemia with excess blasts), MRI showed decreased signal intensity in 76.5% of subjects in the sequences analyzed together. In the group of patients with increased LDH (lactate dehydrogenase), 22 patients (55%) showed decreased signal intensity in the combined analysis of T1- and T2-weighted sequences. Among transfusion-dependent patients, 20 scans (60.6%) showed decreased signal intensity. CONCLUSIONS: As the risk category of MDS increases towards high – bad risk, decreased signal intensity is observed in lumbar spine MRI in T1- and T2-weighted images in all studied stratification scales. There is a positive correlation between decreased signal intensity in lumbar spine MRI examinations and increased LDH level in blood serum, as well as dependence on blood product transfusions, especially packed red blood cells. |
format | Online Article Text |
id | pubmed-4170840 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | International Scientific Literature, Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-41708402014-09-23 Usefulness of Magnetic Resonance Imaging as a Prognostic Variable in Myelodysplastic Syndromes Ziółko, Ewa Kwiatkowska-Pamuła, Anna Adamczyk, Tomasz Walecki, Jerzy Muc-Wierzgoń, Małgorzata Med Sci Monit Clinical Research BACKGROUND: Myelodysplastic syndromes are clonal disorders of stem cells, characterized by heterogeneous clinical presentation. Hematopoiesis is ineffective, characterized by abnormal differentiation, maturation and survival of hematopoietic cells. MATERIAL/METHODS: The examinations were conducted in the Hematology Ward and the Internal Medicine Ward of the Specialist Hospital No. 1 in Bytom in the years 2006–2011. The study group included 53 patients with diagnosed myelodysplastic syndrome. The results of magnetic resonance imaging (MRI) of the spine were obtained from the medical documentation of patients. RESULTS: In the group of patients diagnosed with RT (refractory thrombocytopenia) and in the group diagnosed with RA (refractory anemia), 100% of lumbar spine images in T1- and T2-weighted sequences assessed together showed increased signal intensity. In patients diagnosed with RAEB (refractory anemia with excess blasts), MRI showed decreased signal intensity in 76.5% of subjects in the sequences analyzed together. In the group of patients with increased LDH (lactate dehydrogenase), 22 patients (55%) showed decreased signal intensity in the combined analysis of T1- and T2-weighted sequences. Among transfusion-dependent patients, 20 scans (60.6%) showed decreased signal intensity. CONCLUSIONS: As the risk category of MDS increases towards high – bad risk, decreased signal intensity is observed in lumbar spine MRI in T1- and T2-weighted images in all studied stratification scales. There is a positive correlation between decreased signal intensity in lumbar spine MRI examinations and increased LDH level in blood serum, as well as dependence on blood product transfusions, especially packed red blood cells. International Scientific Literature, Inc. 2014-09-13 /pmc/articles/PMC4170840/ /pubmed/25217620 http://dx.doi.org/10.12659/MSM.890978 Text en © Med Sci Monit, 2014 This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported License |
spellingShingle | Clinical Research Ziółko, Ewa Kwiatkowska-Pamuła, Anna Adamczyk, Tomasz Walecki, Jerzy Muc-Wierzgoń, Małgorzata Usefulness of Magnetic Resonance Imaging as a Prognostic Variable in Myelodysplastic Syndromes |
title | Usefulness of Magnetic Resonance Imaging as a Prognostic Variable in Myelodysplastic Syndromes |
title_full | Usefulness of Magnetic Resonance Imaging as a Prognostic Variable in Myelodysplastic Syndromes |
title_fullStr | Usefulness of Magnetic Resonance Imaging as a Prognostic Variable in Myelodysplastic Syndromes |
title_full_unstemmed | Usefulness of Magnetic Resonance Imaging as a Prognostic Variable in Myelodysplastic Syndromes |
title_short | Usefulness of Magnetic Resonance Imaging as a Prognostic Variable in Myelodysplastic Syndromes |
title_sort | usefulness of magnetic resonance imaging as a prognostic variable in myelodysplastic syndromes |
topic | Clinical Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4170840/ https://www.ncbi.nlm.nih.gov/pubmed/25217620 http://dx.doi.org/10.12659/MSM.890978 |
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