Pronounced Effects of HERG-Blockers E-4031 and Erythromycin on APD, Spatial APD Dispersion and Triangulation in Transgenic Long-QT Type 1 Rabbits

BACKGROUND: Prolongation of action potential duration (APD), increased spatial APD dispersion, and triangulation are major factors promoting drug-induced ventricular arrhythmia. Preclinical identification of HERG/I(Kr)-blocking drugs and their pro-arrhythmic potential, however, remains a challenge....

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Detalles Bibliográficos
Autores principales: Ziupa, David, Beck, Julia, Franke, Gerlind, Perez Feliz, Stefanie, Hartmann, Maximilian, Koren, Gideon, Zehender, Manfred, Bode, Christoph, Brunner, Michael, Odening, Katja E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4170956/
https://www.ncbi.nlm.nih.gov/pubmed/25244401
http://dx.doi.org/10.1371/journal.pone.0107210

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