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Resveratrol Sensitizes Selectively Thyroid Cancer Cell to 131-Iodine Toxicity
Background. In this study, the radiosensitizing effect of resveratrol as a natural product was investigated on cell toxicity induced by (131)I in thyroid cancer cell. Methods. Human thyroid cancer cell and human nonmalignant fibroblast cell (HFFF2) were treated with (131)I and/or resveratrol at diff...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4170962/ https://www.ncbi.nlm.nih.gov/pubmed/25276125 http://dx.doi.org/10.1155/2014/839597 |
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author | Hosseinimehr, Seyed Jalal Hosseini, Seyed Amir Hossein |
author_facet | Hosseinimehr, Seyed Jalal Hosseini, Seyed Amir Hossein |
author_sort | Hosseinimehr, Seyed Jalal |
collection | PubMed |
description | Background. In this study, the radiosensitizing effect of resveratrol as a natural product was investigated on cell toxicity induced by (131)I in thyroid cancer cell. Methods. Human thyroid cancer cell and human nonmalignant fibroblast cell (HFFF2) were treated with (131)I and/or resveratrol at different concentrations for 48 h. The cell proliferation was measured by determination of the percent of the survival cells using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. Results. Findings of this study show that resveratrol enhanced the cell death induced by (131)I on thyroid cancer cell. Also, resveratrol exhibited a protective effect on normal cells against (131)I toxicity. Conclusion. This result indicates a promising effect of resveratrol on improvement of cellular toxicity during iodine therapy. |
format | Online Article Text |
id | pubmed-4170962 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-41709622014-09-28 Resveratrol Sensitizes Selectively Thyroid Cancer Cell to 131-Iodine Toxicity Hosseinimehr, Seyed Jalal Hosseini, Seyed Amir Hossein J Toxicol Research Article Background. In this study, the radiosensitizing effect of resveratrol as a natural product was investigated on cell toxicity induced by (131)I in thyroid cancer cell. Methods. Human thyroid cancer cell and human nonmalignant fibroblast cell (HFFF2) were treated with (131)I and/or resveratrol at different concentrations for 48 h. The cell proliferation was measured by determination of the percent of the survival cells using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. Results. Findings of this study show that resveratrol enhanced the cell death induced by (131)I on thyroid cancer cell. Also, resveratrol exhibited a protective effect on normal cells against (131)I toxicity. Conclusion. This result indicates a promising effect of resveratrol on improvement of cellular toxicity during iodine therapy. Hindawi Publishing Corporation 2014 2014-09-03 /pmc/articles/PMC4170962/ /pubmed/25276125 http://dx.doi.org/10.1155/2014/839597 Text en Copyright © 2014 S. J. Hosseinimehr and S. A. H. Hosseini. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Hosseinimehr, Seyed Jalal Hosseini, Seyed Amir Hossein Resveratrol Sensitizes Selectively Thyroid Cancer Cell to 131-Iodine Toxicity |
title | Resveratrol Sensitizes Selectively Thyroid Cancer Cell to 131-Iodine Toxicity |
title_full | Resveratrol Sensitizes Selectively Thyroid Cancer Cell to 131-Iodine Toxicity |
title_fullStr | Resveratrol Sensitizes Selectively Thyroid Cancer Cell to 131-Iodine Toxicity |
title_full_unstemmed | Resveratrol Sensitizes Selectively Thyroid Cancer Cell to 131-Iodine Toxicity |
title_short | Resveratrol Sensitizes Selectively Thyroid Cancer Cell to 131-Iodine Toxicity |
title_sort | resveratrol sensitizes selectively thyroid cancer cell to 131-iodine toxicity |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4170962/ https://www.ncbi.nlm.nih.gov/pubmed/25276125 http://dx.doi.org/10.1155/2014/839597 |
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