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Resveratrol Sensitizes Selectively Thyroid Cancer Cell to 131-Iodine Toxicity

Background. In this study, the radiosensitizing effect of resveratrol as a natural product was investigated on cell toxicity induced by (131)I in thyroid cancer cell. Methods. Human thyroid cancer cell and human nonmalignant fibroblast cell (HFFF2) were treated with (131)I and/or resveratrol at diff...

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Autores principales: Hosseinimehr, Seyed Jalal, Hosseini, Seyed Amir Hossein
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4170962/
https://www.ncbi.nlm.nih.gov/pubmed/25276125
http://dx.doi.org/10.1155/2014/839597
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author Hosseinimehr, Seyed Jalal
Hosseini, Seyed Amir Hossein
author_facet Hosseinimehr, Seyed Jalal
Hosseini, Seyed Amir Hossein
author_sort Hosseinimehr, Seyed Jalal
collection PubMed
description Background. In this study, the radiosensitizing effect of resveratrol as a natural product was investigated on cell toxicity induced by (131)I in thyroid cancer cell. Methods. Human thyroid cancer cell and human nonmalignant fibroblast cell (HFFF2) were treated with (131)I and/or resveratrol at different concentrations for 48 h. The cell proliferation was measured by determination of the percent of the survival cells using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. Results. Findings of this study show that resveratrol enhanced the cell death induced by (131)I on thyroid cancer cell. Also, resveratrol exhibited a protective effect on normal cells against (131)I toxicity. Conclusion. This result indicates a promising effect of resveratrol on improvement of cellular toxicity during iodine therapy.
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spelling pubmed-41709622014-09-28 Resveratrol Sensitizes Selectively Thyroid Cancer Cell to 131-Iodine Toxicity Hosseinimehr, Seyed Jalal Hosseini, Seyed Amir Hossein J Toxicol Research Article Background. In this study, the radiosensitizing effect of resveratrol as a natural product was investigated on cell toxicity induced by (131)I in thyroid cancer cell. Methods. Human thyroid cancer cell and human nonmalignant fibroblast cell (HFFF2) were treated with (131)I and/or resveratrol at different concentrations for 48 h. The cell proliferation was measured by determination of the percent of the survival cells using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. Results. Findings of this study show that resveratrol enhanced the cell death induced by (131)I on thyroid cancer cell. Also, resveratrol exhibited a protective effect on normal cells against (131)I toxicity. Conclusion. This result indicates a promising effect of resveratrol on improvement of cellular toxicity during iodine therapy. Hindawi Publishing Corporation 2014 2014-09-03 /pmc/articles/PMC4170962/ /pubmed/25276125 http://dx.doi.org/10.1155/2014/839597 Text en Copyright © 2014 S. J. Hosseinimehr and S. A. H. Hosseini. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Hosseinimehr, Seyed Jalal
Hosseini, Seyed Amir Hossein
Resveratrol Sensitizes Selectively Thyroid Cancer Cell to 131-Iodine Toxicity
title Resveratrol Sensitizes Selectively Thyroid Cancer Cell to 131-Iodine Toxicity
title_full Resveratrol Sensitizes Selectively Thyroid Cancer Cell to 131-Iodine Toxicity
title_fullStr Resveratrol Sensitizes Selectively Thyroid Cancer Cell to 131-Iodine Toxicity
title_full_unstemmed Resveratrol Sensitizes Selectively Thyroid Cancer Cell to 131-Iodine Toxicity
title_short Resveratrol Sensitizes Selectively Thyroid Cancer Cell to 131-Iodine Toxicity
title_sort resveratrol sensitizes selectively thyroid cancer cell to 131-iodine toxicity
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4170962/
https://www.ncbi.nlm.nih.gov/pubmed/25276125
http://dx.doi.org/10.1155/2014/839597
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