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The Role of Galectin-1 and Galectin-3 in the Mucosal Immune Response to Citrobacter rodentium Infection

Despite their abundance at gastrointestinal sites, little is known about the role of galectins in gut immune responses. We have therefore investigated the Citrobacter rodentium model of colonic infection and inflammation in Galectin-1 or Galectin-3 null mice. Gal-3 null mice showed a slight delay in...

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Autores principales: Curciarello, Renata, Steele, Alison, Cooper, Dianne, MacDonald, Thomas T., Kruidenier, Laurens, Kudo, Takahiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4171484/
https://www.ncbi.nlm.nih.gov/pubmed/25243744
http://dx.doi.org/10.1371/journal.pone.0107933
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author Curciarello, Renata
Steele, Alison
Cooper, Dianne
MacDonald, Thomas T.
Kruidenier, Laurens
Kudo, Takahiro
author_facet Curciarello, Renata
Steele, Alison
Cooper, Dianne
MacDonald, Thomas T.
Kruidenier, Laurens
Kudo, Takahiro
author_sort Curciarello, Renata
collection PubMed
description Despite their abundance at gastrointestinal sites, little is known about the role of galectins in gut immune responses. We have therefore investigated the Citrobacter rodentium model of colonic infection and inflammation in Galectin-1 or Galectin-3 null mice. Gal-3 null mice showed a slight delay in colonisation after inoculation with C. rodentium and a slight delay in resolution of infection, associated with delayed T cell, macrophage and dendritic cell infiltration into the gut mucosa. However, Gal-1 null mice also demonstrated reduced T cell and macrophage responses to infection. Despite the reduced T cell and macrophage response in Gal-1 null mice, there was no effect on C. rodentium infection kinetics and pathology. Overall, Gal-1 and Gal-3 play only a minor role in immunity to a gut bacterial pathogen.
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spelling pubmed-41714842014-09-25 The Role of Galectin-1 and Galectin-3 in the Mucosal Immune Response to Citrobacter rodentium Infection Curciarello, Renata Steele, Alison Cooper, Dianne MacDonald, Thomas T. Kruidenier, Laurens Kudo, Takahiro PLoS One Research Article Despite their abundance at gastrointestinal sites, little is known about the role of galectins in gut immune responses. We have therefore investigated the Citrobacter rodentium model of colonic infection and inflammation in Galectin-1 or Galectin-3 null mice. Gal-3 null mice showed a slight delay in colonisation after inoculation with C. rodentium and a slight delay in resolution of infection, associated with delayed T cell, macrophage and dendritic cell infiltration into the gut mucosa. However, Gal-1 null mice also demonstrated reduced T cell and macrophage responses to infection. Despite the reduced T cell and macrophage response in Gal-1 null mice, there was no effect on C. rodentium infection kinetics and pathology. Overall, Gal-1 and Gal-3 play only a minor role in immunity to a gut bacterial pathogen. Public Library of Science 2014-09-22 /pmc/articles/PMC4171484/ /pubmed/25243744 http://dx.doi.org/10.1371/journal.pone.0107933 Text en © 2014 Curciarello et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Curciarello, Renata
Steele, Alison
Cooper, Dianne
MacDonald, Thomas T.
Kruidenier, Laurens
Kudo, Takahiro
The Role of Galectin-1 and Galectin-3 in the Mucosal Immune Response to Citrobacter rodentium Infection
title The Role of Galectin-1 and Galectin-3 in the Mucosal Immune Response to Citrobacter rodentium Infection
title_full The Role of Galectin-1 and Galectin-3 in the Mucosal Immune Response to Citrobacter rodentium Infection
title_fullStr The Role of Galectin-1 and Galectin-3 in the Mucosal Immune Response to Citrobacter rodentium Infection
title_full_unstemmed The Role of Galectin-1 and Galectin-3 in the Mucosal Immune Response to Citrobacter rodentium Infection
title_short The Role of Galectin-1 and Galectin-3 in the Mucosal Immune Response to Citrobacter rodentium Infection
title_sort role of galectin-1 and galectin-3 in the mucosal immune response to citrobacter rodentium infection
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4171484/
https://www.ncbi.nlm.nih.gov/pubmed/25243744
http://dx.doi.org/10.1371/journal.pone.0107933
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