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Family-Based Association Test Using Both Common and Rare Variants and Accounting for Directions of Effects for Sequencing Data

Current family-based association tests for sequencing data were mainly developed for identifying rare variants associated with a complex disease. As the disease can be influenced by the joint effects of common and rare variants, common variants with modest effects may not be identified by the method...

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Detalles Bibliográficos
Autores principales: Chung, Ren-Hua, Tsai, Wei-Yun, Martin, Eden R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4171487/
https://www.ncbi.nlm.nih.gov/pubmed/25244564
http://dx.doi.org/10.1371/journal.pone.0107800

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