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Ontogeny of small RNA in the regulation of mammalian brain development
BACKGROUND: MicroRNAs (miRNAs) play a pivotal role in coordinating messenger RNA (mRNA) transcription and stability in almost all known biological processes, including the development of the central nervous system. Despite our broad understanding of their involvement, we still have a very sparse und...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4171549/ https://www.ncbi.nlm.nih.gov/pubmed/25204312 http://dx.doi.org/10.1186/1471-2164-15-777 |
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author | Hollins, Sharon L Goldie, Belinda J Carroll, Adam P Mason, Elizabeth A Walker, Frederick R Eyles, Darryl W Cairns, Murray J |
author_facet | Hollins, Sharon L Goldie, Belinda J Carroll, Adam P Mason, Elizabeth A Walker, Frederick R Eyles, Darryl W Cairns, Murray J |
author_sort | Hollins, Sharon L |
collection | PubMed |
description | BACKGROUND: MicroRNAs (miRNAs) play a pivotal role in coordinating messenger RNA (mRNA) transcription and stability in almost all known biological processes, including the development of the central nervous system. Despite our broad understanding of their involvement, we still have a very sparse understanding of specifically how miRNA contribute to the strict regional and temporal regulation of brain development. Accordingly, in the current study we have examined the contribution of miRNA in the developing rat telencephalon and mesencephalon from just after neural tube closure till birth using a genome-wide microarray strategy. RESULTS: We identified temporally distinct expression patterns in both the telencephalon and mesencephalon for both miRNAs and their target genes. We demonstrate direct miRNA targeting of several genes involved with the migration, differentiation and maturation of neurons. CONCLUSIONS: Our findings suggest that miRNA have significant implications for the development of neural structure and support important mechanisms that if disrupted, may contribute to or drive neurodevelopmental disorders. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/1471-2164-15-777) contains supplementary material, which is available to authorized users. |
format | Online Article Text |
id | pubmed-4171549 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-41715492014-09-24 Ontogeny of small RNA in the regulation of mammalian brain development Hollins, Sharon L Goldie, Belinda J Carroll, Adam P Mason, Elizabeth A Walker, Frederick R Eyles, Darryl W Cairns, Murray J BMC Genomics Research Article BACKGROUND: MicroRNAs (miRNAs) play a pivotal role in coordinating messenger RNA (mRNA) transcription and stability in almost all known biological processes, including the development of the central nervous system. Despite our broad understanding of their involvement, we still have a very sparse understanding of specifically how miRNA contribute to the strict regional and temporal regulation of brain development. Accordingly, in the current study we have examined the contribution of miRNA in the developing rat telencephalon and mesencephalon from just after neural tube closure till birth using a genome-wide microarray strategy. RESULTS: We identified temporally distinct expression patterns in both the telencephalon and mesencephalon for both miRNAs and their target genes. We demonstrate direct miRNA targeting of several genes involved with the migration, differentiation and maturation of neurons. CONCLUSIONS: Our findings suggest that miRNA have significant implications for the development of neural structure and support important mechanisms that if disrupted, may contribute to or drive neurodevelopmental disorders. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/1471-2164-15-777) contains supplementary material, which is available to authorized users. BioMed Central 2014-09-09 /pmc/articles/PMC4171549/ /pubmed/25204312 http://dx.doi.org/10.1186/1471-2164-15-777 Text en © Hollins et al.; licensee BioMed Central Ltd. 2014 This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Research Article Hollins, Sharon L Goldie, Belinda J Carroll, Adam P Mason, Elizabeth A Walker, Frederick R Eyles, Darryl W Cairns, Murray J Ontogeny of small RNA in the regulation of mammalian brain development |
title | Ontogeny of small RNA in the regulation of mammalian brain development |
title_full | Ontogeny of small RNA in the regulation of mammalian brain development |
title_fullStr | Ontogeny of small RNA in the regulation of mammalian brain development |
title_full_unstemmed | Ontogeny of small RNA in the regulation of mammalian brain development |
title_short | Ontogeny of small RNA in the regulation of mammalian brain development |
title_sort | ontogeny of small rna in the regulation of mammalian brain development |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4171549/ https://www.ncbi.nlm.nih.gov/pubmed/25204312 http://dx.doi.org/10.1186/1471-2164-15-777 |
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