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Ethylene Glycol Ethers Induce Oxidative Stress in the Rat Brain
Ethylene glycol ethers (EGEs) are components of many industrial and household products. Their hemolytic and gonadotoxic effects are relatively well known while their potential adverse effects on the central nervous system have not yet been clearly demonstrated. The aim of the present study was to ex...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer US
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4171594/ https://www.ncbi.nlm.nih.gov/pubmed/25085197 http://dx.doi.org/10.1007/s12640-014-9486-8 |
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author | Pomierny, Bartosz Krzyżanowska, Weronika Smaga, Irena Pomierny-Chamioło, Lucyna Stankowicz, Piotr Budziszewska, Bogusława |
author_facet | Pomierny, Bartosz Krzyżanowska, Weronika Smaga, Irena Pomierny-Chamioło, Lucyna Stankowicz, Piotr Budziszewska, Bogusława |
author_sort | Pomierny, Bartosz |
collection | PubMed |
description | Ethylene glycol ethers (EGEs) are components of many industrial and household products. Their hemolytic and gonadotoxic effects are relatively well known while their potential adverse effects on the central nervous system have not yet been clearly demonstrated. The aim of the present study was to examine the effects of 4-week administration of 2-buthoxyethanol (BE), 2-phenoxyethanol (PHE) and 2-ethoxyethanol (EE) on the total antioxidant capacity, activity of some antioxidant enzymes, such as the superoxide dismutase (SOD), catalase, glutathione peroxidase (GPX) and glutathione reductase and lipid peroxidation in the frontal cortex and hippocampus in the rat. These studies showed that BE and PHE decreased the total antioxidant activity, SOD and GPX activity, while increased lipid peroxidation in the frontal cortex. Like in the frontal cortex, also in the hippocampus BE and PHE attenuated the total antioxidant activity, however, lipid peroxidation was increased only in animals which received BE while reduction in GPX activity was present in rats administered PHE. The obtained data indicated that 4-week administration of BE and PHE, but not EE, reduced the total antioxidant activity and enhanced lipid peroxidation in the brain. In the frontal cortex, adverse effects of PHE and BE on lipid peroxidation probably depended on reduction in SOD and GPX activity, however, in the hippocampus the changes in the total antioxidant activity and lipid peroxidation were not connected with reduction of the investigated antioxidant enzyme activity. |
format | Online Article Text |
id | pubmed-4171594 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Springer US |
record_format | MEDLINE/PubMed |
spelling | pubmed-41715942014-09-24 Ethylene Glycol Ethers Induce Oxidative Stress in the Rat Brain Pomierny, Bartosz Krzyżanowska, Weronika Smaga, Irena Pomierny-Chamioło, Lucyna Stankowicz, Piotr Budziszewska, Bogusława Neurotox Res Brief Communication Ethylene glycol ethers (EGEs) are components of many industrial and household products. Their hemolytic and gonadotoxic effects are relatively well known while their potential adverse effects on the central nervous system have not yet been clearly demonstrated. The aim of the present study was to examine the effects of 4-week administration of 2-buthoxyethanol (BE), 2-phenoxyethanol (PHE) and 2-ethoxyethanol (EE) on the total antioxidant capacity, activity of some antioxidant enzymes, such as the superoxide dismutase (SOD), catalase, glutathione peroxidase (GPX) and glutathione reductase and lipid peroxidation in the frontal cortex and hippocampus in the rat. These studies showed that BE and PHE decreased the total antioxidant activity, SOD and GPX activity, while increased lipid peroxidation in the frontal cortex. Like in the frontal cortex, also in the hippocampus BE and PHE attenuated the total antioxidant activity, however, lipid peroxidation was increased only in animals which received BE while reduction in GPX activity was present in rats administered PHE. The obtained data indicated that 4-week administration of BE and PHE, but not EE, reduced the total antioxidant activity and enhanced lipid peroxidation in the brain. In the frontal cortex, adverse effects of PHE and BE on lipid peroxidation probably depended on reduction in SOD and GPX activity, however, in the hippocampus the changes in the total antioxidant activity and lipid peroxidation were not connected with reduction of the investigated antioxidant enzyme activity. Springer US 2014-08-02 2014 /pmc/articles/PMC4171594/ /pubmed/25085197 http://dx.doi.org/10.1007/s12640-014-9486-8 Text en © The Author(s) 2014 https://creativecommons.org/licenses/by/4.0/ Open AccessThis article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited. |
spellingShingle | Brief Communication Pomierny, Bartosz Krzyżanowska, Weronika Smaga, Irena Pomierny-Chamioło, Lucyna Stankowicz, Piotr Budziszewska, Bogusława Ethylene Glycol Ethers Induce Oxidative Stress in the Rat Brain |
title | Ethylene Glycol Ethers Induce Oxidative Stress in the Rat Brain |
title_full | Ethylene Glycol Ethers Induce Oxidative Stress in the Rat Brain |
title_fullStr | Ethylene Glycol Ethers Induce Oxidative Stress in the Rat Brain |
title_full_unstemmed | Ethylene Glycol Ethers Induce Oxidative Stress in the Rat Brain |
title_short | Ethylene Glycol Ethers Induce Oxidative Stress in the Rat Brain |
title_sort | ethylene glycol ethers induce oxidative stress in the rat brain |
topic | Brief Communication |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4171594/ https://www.ncbi.nlm.nih.gov/pubmed/25085197 http://dx.doi.org/10.1007/s12640-014-9486-8 |
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