Eradication of metastatic melanoma through cooperative expression of RNA-based HDAC1 inhibitor and p73 by oncolytic adenovirus

Malignant melanoma is a highly aggressive cancer that retains functional p53 and p73, and drug unresponsiveness largely depends on defects in death pathways after epigenetic gene silencing in conjunction with an imbalanced p73/DNp73 ratio. We constructed oncolytic viruses armed with an inhibitor of...

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Detalles Bibliográficos
Autores principales: Schipper, Holger, Alla, Vijay, Meier, Claudia, Nettelbeck, Dirk M., Herchenröder, Ottmar, Pützer, Brigitte M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2014
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4171600/
https://www.ncbi.nlm.nih.gov/pubmed/25071017

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