Nuclear HER4 mediates acquired resistance to trastuzumab and is associated with poor outcome in HER2 positive breast cancer

The role of HER4 in breast cancer is controversial and its role in relation to trastuzumab resistance remains unclear. We showed that trastuzumab treatment and its acquired resistance induced HER4 upregulation, cleavage and nuclear translocation. However, knockdown of HER4 by specific siRNAs increas...

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Detalles Bibliográficos
Autores principales: Nafi, Siti Norasikin Mohd, Generali, Daniele, Kramer-Marek, Gabriela, Gijsen, Merel, Strina, Carla, Cappelletti, Mariarosa, Andreis, Daniele, Haider, Syed, Li, Ji-Liang, Bridges, Esther, Capala, Jacek, Ioannis, Roxanis, Harris, Adrian L, Kong, Anthony
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2014
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4171603/
https://www.ncbi.nlm.nih.gov/pubmed/25153719

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