The stress phenotype makes cancer cells addicted to CDT2, a substrate receptor of the CRL4 ubiquitin ligase

CDT2/L2DTL/RAMP is one of the substrate receptors of the Cullin Ring Ubiquitin Ligase 4 that targets for ubiquitin mediated degradation a number of substrates, such as CDT1, p21 and CHK1, involved in the regulation of cell cycle and survival. Here we show that CDT2 depletion was alone able to induce...

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Detalles Bibliográficos
Autores principales: Olivero, Martina, Dettori, Daniela, Arena, Sabrina, Zecchin, Davide, Lantelme, Erica, Di Renzo, Maria Flavia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2014
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4171607/
https://www.ncbi.nlm.nih.gov/pubmed/25115388

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