Oncogenic KIT-induced aggressive systemic mastocytosis requires SHP2/PTPN11 phosphatase for disease progression in mice

Acquired mutations in KIT are driver mutations in systemic mastocytosis (SM). Here, we tested the role of SHP2/PTPN11 phosphatase in oncogenic KIT signaling using an aggressive SM mouse model. Stable knock-down (KD) of SHP2 led to impaired growth, colony formation, and increased rates of apoptosis i...

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Detalles Bibliográficos
Autores principales: Sharma, Namit, Everingham, Stephanie, Zeng, Li-Fan, Zhang, Zhong-Yin, Kapur, Reuben, Craig, Andrew W.B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2014
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4171618/
https://www.ncbi.nlm.nih.gov/pubmed/25026279

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