AKT regulates NPM dependent ARF localization and p53(mut) stability in tumors

Nucleophosmin (NPM) is known to regulate ARF subcellular localization and MDM2 activity in response to oncogenic stress, though the precise mechanism has remained elusive. Here we describe how NPM and ARF associate in the nucleoplasm to form a MDM2 inhibitory complex. We find that oligomerization of...

Descripción completa

Detalles Bibliográficos
Autores principales: Hamilton, Garth, Abraham, Aswin G., Morton, Jennifer, Sampson, Oliver, Pefani, Dafni E., Khoronenkova, Svetlana, Grawenda, Anna, Papaspyropoulos, Angelos, Jamieson, Nigel, McKay, Colin, Sansom, Owen, Dianov, Grigory L., O'Neill, Eric
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2014
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4171619/
https://www.ncbi.nlm.nih.gov/pubmed/25071014

Ejemplares similares

Ejemplares similares