Overexpression of HMGB1 in melanoma predicts patient survival and suppression of HMGB1 induces cell cycle arrest and senescence in association with p21 (Waf1/Cip1) up-regulation via a p53-independent, Sp1-dependent pathway

Although laboratory studies have implicated the high mobility group box 1 (HMGB1) in melanoma, its clinical relevance remains unclear. We analyzed nearly 100 cases of human melanoma and found that HMGB1 was highly overexpressed in melanoma samples relative to normal skin and nevi tissues. Significan...

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Detalles Bibliográficos
Autores principales: Li, Qingling, Li, Jie, Wen, Ting, Zeng, Weiqi, Peng, Cong, Yan, Siyu, Tan, Jieqiong, Yang, Keda, Liu, Shuang, Guo, Aiyuan, Zhang, Chong, Su, Juan, Jiang, Minghao, Liu, Zhaoqian, Zhou, Honghao, Chen, Xiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2014
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4171638/
https://www.ncbi.nlm.nih.gov/pubmed/25051367

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