Increased DNA Methyltransferase 3b (Dnmt3b)-Mediated CpG Island Methylation Stimulated by Oxidative Stress Inhibits Expression of a Gene Required for Neural Tube and Neural Crest Development in Diabetic Pregnancy

Previous studies have shown that diabetic embryopathy results from impaired expression of genes that are required for formation of embryonic structures. We have focused on Pax3, a gene that is expressed in embryonic neuroepithelium and is required for neural tube closure. Pax3 expression is inhibite...

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Detalles Bibliográficos
Autores principales: Wei, Dan, Loeken, Mary R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Diabetes Association 2014
Materias:
Complications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4171658/
https://www.ncbi.nlm.nih.gov/pubmed/24834974
http://dx.doi.org/10.2337/db14-0231

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4171658/
https://www.ncbi.nlm.nih.gov/pubmed/24834974
http://dx.doi.org/10.2337/db14-0231

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