Cargando…

Palmitate Induces mRNA Translation and Increases ER Protein Load in Islet β-Cells via Activation of the Mammalian Target of Rapamycin Pathway

Saturated free fatty acids (FFAs) have complex effects on the islet β-cell, acutely promoting adaptive hyperplasia but chronically impairing insulin release. The acute effects of FFAs remain incompletely defined. To elucidate these early molecular events, we incubated mouse β-cells and islets with p...

Descripción completa

Detalles Bibliográficos
Autores principales:	Hatanaka, Masayuki, Maier, Bernhard, Sims, Emily K., Templin, Andrew T., Kulkarni, Rohit N., Evans-Molina, Carmella, Mirmira, Raghavendra G.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Diabetes Association 2014
Materias:	Islet Studies
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4171659/ https://www.ncbi.nlm.nih.gov/pubmed/24834975 http://dx.doi.org/10.2337/db14-0105

Ejemplares similares

Islet β-Cell Endoplasmic Reticulum Stress Precedes the Onset of Type 1 Diabetes in the Nonobese Diabetic Mouse Model
por: Tersey, Sarah A., et al.
Publicado: (2012)

Methyltransferase Set7/9 Maintains Transcription and Euchromatin Structure at Islet-Enriched Genes
por: Deering, Tye G., et al.
Publicado: (2009)

Chronic high fat feeding restricts islet mRNA translation initiation independently of ER stress via DNA damage and p53 activation
por: Hatanaka, Masayuki, et al.
Publicado: (2017)

Δ40 Isoform of p53 Controls β-Cell Proliferation and Glucose Homeostasis in Mice
por: Hinault, Charlotte, et al.
Publicado: (2011)

Glycogen Synthase Kinase-3 and Mammalian Target of Rapamycin Pathways Contribute to DNA Synthesis, Cell Cycle Progression, and Proliferation in Human Islets
por: Liu, Hui, et al.
Publicado: (2009)

Palmitate Impairs and Eicosapentaenoate Restores Insulin Secretion Through Regulation of SREBP-1c in Pancreatic Islets
por: Kato, Toyonori, et al.
Publicado: (2008)

Elevations in Circulating Methylated and Unmethylated Preproinsulin DNA in New-Onset Type 1 Diabetes
por: Fisher, Marisa M., et al.
Publicado: (2015)

Insulin Resistance Alters Islet Morphology in Nondiabetic Humans
por: Mezza, Teresa, et al.
Publicado: (2014)

The Hypoglycemic Phenotype Is Islet Cell–Autonomous in Short-Chain Hydroxyacyl-CoA Dehydrogenase–Deficient Mice
por: Molven, Anders, et al.
Publicado: (2016)

Control of Insulin Secretion by Cholinergic Signaling in the Human Pancreatic Islet
por: Molina, Judith, et al.
Publicado: (2014)

Intracutaneous Transplantation of Islets Within a Biodegradable Temporizing Matrix as an Alternative Site for Islet Transplantation
por: Rojas-Canales, Darling, et al.
Publicado: (2023)

β-Cell Glucose Sensitivity to Assess Changes in β-Cell Function in Recent-Onset Stage 3 Type 1 Diabetes
por: Gitelman, Stephen E., et al.
Publicado: (2023)

Somatostatin Secreted by Islet δ-Cells Fulfills Multiple Roles as a Paracrine Regulator of Islet Function
por: Hauge-Evans, Astrid C., et al.
Publicado: (2009)

Interleukin-6 Reduces β-Cell Oxidative Stress by Linking Autophagy With the Antioxidant Response
por: Marasco, Michelle R., et al.
Publicado: (2018)

Formation of Composite Endothelial Cell–Mesenchymal Stem Cell Islets: A Novel Approach to Promote Islet Revascularization
por: Johansson, Ulrika, et al.
Publicado: (2008)

Islet α-, β-, and δ-Cell Development Is Controlled by the Ldb1 Coregulator, Acting Primarily With the Islet-1 Transcription Factor
por: Hunter, Chad S., et al.
Publicado: (2013)

Mafa Enables Pdx1 to Effectively Convert Pancreatic Islet Progenitors and Committed Islet α-Cells Into β-Cells In Vivo
por: Matsuoka, Taka-aki, et al.
Publicado: (2017)

Islet-1 Is Essential for Pancreatic β-Cell Function
por: Ediger, Benjamin N., et al.
Publicado: (2014)

Small Interfering RNA–Mediated Suppression of Proislet Amyloid Polypeptide Expression Inhibits Islet Amyloid Formation and Enhances Survival of Human Islets in Culture
por: Marzban, Lucy, et al.
Publicado: (2008)

ADCY5 Couples Glucose to Insulin Secretion in Human Islets
por: Hodson, David J., et al.
Publicado: (2014)

A Smad Signaling Network Regulates Islet Cell Proliferation
por: El-Gohary, Yousef, et al.
Publicado: (2014)

Enterovirus infection of human islets of Langerhans affects β-cell function resulting in disintegrated islets, decreased glucose stimulated insulin secretion and loss of Golgi structure
por: Hodik, M, et al.
Publicado: (2016)

Hepatocyte Growth Factor Enhances Engraftment and Function of Nonhuman Primate Islets
por: Fiaschi-Taesch, Nathalie M., et al.
Publicado: (2008)

Cytokine and Chemokine Production by Human Pancreatic Islets Upon Enterovirus Infection
por: Schulte, Barbara M., et al.
Publicado: (2012)

Profiling of RNAs from Human Islet-Derived Exosomes in a Model of Type 1 Diabetes
por: Krishnan, Preethi, et al.
Publicado: (2019)

Thrombospondin-1: An Islet Endothelial Cell Signal of Importance for β-Cell Function
por: Olerud, Johan, et al.
Publicado: (2011)

High-Resolution Magnetic Resonance Imaging Quantitatively Detects Individual Pancreatic Islets
por: Lamprianou, Smaragda, et al.
Publicado: (2011)

Monitoring C-Peptide Storage and Secretion in Islet β-Cells In Vitro and In Vivo
por: Zhu, Shuaishuai, et al.
Publicado: (2016)

Islet inflammation is associated with pancreatic fatty infiltration and hyperglycemia in type 2 diabetes
por: Horii, Tomomi, et al.
Publicado: (2020)

Pancreatic β-Cells Express the Fetal Islet Hormone Gastrin in Rodent and Human Diabetes
por: Dahan, Tehila, et al.
Publicado: (2017)

Synaptotagmin-7 Functions to Replenish Insulin Granules for Exocytosis in Human Islet β-Cells
por: Dolai, Subhankar, et al.
Publicado: (2016)

Pericyte Control of Blood Flow in Intraocular Islet Grafts Impacts Glucose Homeostasis in Mice
por: Tamayo, Alejandro, et al.
Publicado: (2022)

Increased Phagocyte-Like NADPH Oxidase and ROS Generation in Type 2 Diabetic ZDF Rat and Human Islets: Role of Rac1–JNK1/2 Signaling Pathway in Mitochondrial Dysregulation in the Diabetic Islet
por: Syed, Ismail, et al.
Publicado: (2011)

Stromal Interaction Molecule 1 Maintains β-Cell Identity and Function in Female Mice Through Preservation of G-Protein–Coupled Estrogen Receptor 1 Signaling
por: Sohn, Paul, et al.
Publicado: (2023)

Switching-On Survival and Repair Response Programs in Islet Transplants by Bone Marrow–Derived Vasculogenic Cells
por: Miller, Robyn, et al.
Publicado: (2008)

Ghrelin Attenuates cAMP-PKA Signaling to Evoke Insulinostatic Cascade in Islet β-Cells
por: Dezaki, Katsuya, et al.
Publicado: (2011)

Islet Cholesterol Accumulation Due to Loss of ABCA1 Leads to Impaired Exocytosis of Insulin Granules
por: Kruit, Janine K., et al.
Publicado: (2011)

Exosomes Released by Islet-Derived Mesenchymal Stem Cells Trigger Autoimmune Responses in NOD Mice
por: Rahman, Muhammad Jubayer, et al.
Publicado: (2014)

The MafA Transcription Factor Becomes Essential to Islet β-Cells Soon After Birth
por: Hang, Yan, et al.
Publicado: (2014)

Novel Stable Isotope Analyses Demonstrate Significant Rates of Glucose Cycling in Mouse Pancreatic Islets
por: Wall, Martha L., et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_sl305kun91tcojquorjiucbkjv