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Importance of Universal screening for thyroid disorders in first trimester of pregnancy

OBJECTIVE: To determine the importance of screening for Thyriod disorders in the first trimester of pregnancy. MATERIALS AND METHODS: The Study was conducted on 305 patients which were were randomly selected and screened on OPD basis by TSH levels (cut off level 0.10-2.50 mIU/ml). RESULTS: In the 30...

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Autores principales: Dave, Anupama, Maru, Laxmi, Tripathi, Megha
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4171902/
https://www.ncbi.nlm.nih.gov/pubmed/25285296
http://dx.doi.org/10.4103/2230-8210.139221
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author Dave, Anupama
Maru, Laxmi
Tripathi, Megha
author_facet Dave, Anupama
Maru, Laxmi
Tripathi, Megha
author_sort Dave, Anupama
collection PubMed
description OBJECTIVE: To determine the importance of screening for Thyriod disorders in the first trimester of pregnancy. MATERIALS AND METHODS: The Study was conducted on 305 patients which were were randomly selected and screened on OPD basis by TSH levels (cut off level 0.10-2.50 mIU/ml). RESULTS: In the 305 women screened mean age was 24.46 years, mean gestational age was 9.09 weeks, 89.83% were euthyroid, 9.8%were hypothyroid, 0.32% were hyperthyroid. Incidence of hypothyroidism in high risk population was 20.58% and in normal population was 6.7%. There was significant association of thyroid disorders with high risk factors (P < 0.001). In hypothyroid women 46% had adverse perinatal outcomes and 53.33% had normal outcomes. This shows statistically significant association abnormal TSH values with adverse pregnancy outcomes (P < 0.001). In abnormal perinatal outcomes 6.2% women had Caesarean section out of them 73.68% were euthyroid, 26.31% were hypothyroid 1.9% had preterm labour, out of them 50% were euthyroid, 50% were hypothyroid. Out of 2.2% spontaneous abortions 28.5% were in euthyroid group while 71.4% were in hypothyroid group. There was 1 term stillbirth in hypothyroid group. This study showed significant association between abnormal thyroid stimulating hormone (TSH) values and adverse perinatal outcomes (P < 0.001). CONCLUSION: There is significant correlation between risk factors and hypothyroidism. So high risk screening is mandatory in early pregnancy. But if we screen only high risk population we would miss 4.6% cases which could have been diagnosed and treated earlier. Therefore it is important to screen all pregnant women in the first trimester, it should be made mandatory.
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spelling pubmed-41719022014-10-03 Importance of Universal screening for thyroid disorders in first trimester of pregnancy Dave, Anupama Maru, Laxmi Tripathi, Megha Indian J Endocrinol Metab Brief Communication OBJECTIVE: To determine the importance of screening for Thyriod disorders in the first trimester of pregnancy. MATERIALS AND METHODS: The Study was conducted on 305 patients which were were randomly selected and screened on OPD basis by TSH levels (cut off level 0.10-2.50 mIU/ml). RESULTS: In the 305 women screened mean age was 24.46 years, mean gestational age was 9.09 weeks, 89.83% were euthyroid, 9.8%were hypothyroid, 0.32% were hyperthyroid. Incidence of hypothyroidism in high risk population was 20.58% and in normal population was 6.7%. There was significant association of thyroid disorders with high risk factors (P < 0.001). In hypothyroid women 46% had adverse perinatal outcomes and 53.33% had normal outcomes. This shows statistically significant association abnormal TSH values with adverse pregnancy outcomes (P < 0.001). In abnormal perinatal outcomes 6.2% women had Caesarean section out of them 73.68% were euthyroid, 26.31% were hypothyroid 1.9% had preterm labour, out of them 50% were euthyroid, 50% were hypothyroid. Out of 2.2% spontaneous abortions 28.5% were in euthyroid group while 71.4% were in hypothyroid group. There was 1 term stillbirth in hypothyroid group. This study showed significant association between abnormal thyroid stimulating hormone (TSH) values and adverse perinatal outcomes (P < 0.001). CONCLUSION: There is significant correlation between risk factors and hypothyroidism. So high risk screening is mandatory in early pregnancy. But if we screen only high risk population we would miss 4.6% cases which could have been diagnosed and treated earlier. Therefore it is important to screen all pregnant women in the first trimester, it should be made mandatory. Medknow Publications & Media Pvt Ltd 2014 /pmc/articles/PMC4171902/ /pubmed/25285296 http://dx.doi.org/10.4103/2230-8210.139221 Text en Copyright: © Indian Journal of Endocrinology and Metabolism http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Brief Communication
Dave, Anupama
Maru, Laxmi
Tripathi, Megha
Importance of Universal screening for thyroid disorders in first trimester of pregnancy
title Importance of Universal screening for thyroid disorders in first trimester of pregnancy
title_full Importance of Universal screening for thyroid disorders in first trimester of pregnancy
title_fullStr Importance of Universal screening for thyroid disorders in first trimester of pregnancy
title_full_unstemmed Importance of Universal screening for thyroid disorders in first trimester of pregnancy
title_short Importance of Universal screening for thyroid disorders in first trimester of pregnancy
title_sort importance of universal screening for thyroid disorders in first trimester of pregnancy
topic Brief Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4171902/
https://www.ncbi.nlm.nih.gov/pubmed/25285296
http://dx.doi.org/10.4103/2230-8210.139221
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