FIRST REPORT ON OTOTOXICITY OF MEGLUMINE ANTIMONIATE

Introduction: Pentavalent antimonials are the first drug of choice in the treatment of tegumentary leishmaniasis. Data on ototoxicity related with such drugs is scarcely available in literature, leading us to develop a study on cochleovestibular functions. Case Report: A case of a tegumentary leishm...

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Detalles Bibliográficos
Autores principales: Valete-Rosalino, Cláudia Maria, Araujo-Melo, Maria Helena, Bezerra, Débora Cristina de Oliveira, de Barcelos, Renata Oliveira, de Melo-Ferreira, Vanessa, Torraca, Tânia Salgado de Sousa, Martins, Ana Cristina da Costa, Moreira, João Soares, Vargas, Mirian Catherine Melgares, Braga, Frederico Pereira Bom, Salgueiro, Mariza de Matos, Saheki, Maurício Naoto, Schubach, Armando Oliveira
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Instituto de Medicina Tropical 2014
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4172117/
https://www.ncbi.nlm.nih.gov/pubmed/25229226
http://dx.doi.org/10.1590/S0036-46652014000500012
Descripción
Sumario:Introduction: Pentavalent antimonials are the first drug of choice in the treatment of tegumentary leishmaniasis. Data on ototoxicity related with such drugs is scarcely available in literature, leading us to develop a study on cochleovestibular functions. Case Report: A case of a tegumentary leishmaniasis patient, a 78-year-old man who presented a substantial increase in auditory threshold with tinnitus and severe rotatory dizziness during the treatment with meglumine antimoniate, is reported. These symptoms worsened in two weeks after treatment was interrupted. Conclusion: Dizziness and tinnitus had already been related to meglumine antimoniate. However, this is the first well documented case of cochlear-vestibular toxicity related to meglumine antimoniate.

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