FIRST REPORT ON OTOTOXICITY OF MEGLUMINE ANTIMONIATE

Introduction: Pentavalent antimonials are the first drug of choice in the treatment of tegumentary leishmaniasis. Data on ototoxicity related with such drugs is scarcely available in literature, leading us to develop a study on cochleovestibular functions. Case Report: A case of a tegumentary leishm...

Descripción completa

Detalles Bibliográficos
Autores principales: Valete-Rosalino, Cláudia Maria, Araujo-Melo, Maria Helena, Bezerra, Débora Cristina de Oliveira, de Barcelos, Renata Oliveira, de Melo-Ferreira, Vanessa, Torraca, Tânia Salgado de Sousa, Martins, Ana Cristina da Costa, Moreira, João Soares, Vargas, Mirian Catherine Melgares, Braga, Frederico Pereira Bom, Salgueiro, Mariza de Matos, Saheki, Maurício Naoto, Schubach, Armando Oliveira
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Instituto de Medicina Tropical 2014
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4172117/
https://www.ncbi.nlm.nih.gov/pubmed/25229226
http://dx.doi.org/10.1590/S0036-46652014000500012
_version_ 1782336009072017408
author Valete-Rosalino, Cláudia Maria
Araujo-Melo, Maria Helena
Bezerra, Débora Cristina de Oliveira
de Barcelos, Renata Oliveira
de Melo-Ferreira, Vanessa
Torraca, Tânia Salgado de Sousa
Martins, Ana Cristina da Costa
Moreira, João Soares
Vargas, Mirian Catherine Melgares
Braga, Frederico Pereira Bom
Salgueiro, Mariza de Matos
Saheki, Maurício Naoto
Schubach, Armando Oliveira
author_facet Valete-Rosalino, Cláudia Maria
Araujo-Melo, Maria Helena
Bezerra, Débora Cristina de Oliveira
de Barcelos, Renata Oliveira
de Melo-Ferreira, Vanessa
Torraca, Tânia Salgado de Sousa
Martins, Ana Cristina da Costa
Moreira, João Soares
Vargas, Mirian Catherine Melgares
Braga, Frederico Pereira Bom
Salgueiro, Mariza de Matos
Saheki, Maurício Naoto
Schubach, Armando Oliveira
author_sort Valete-Rosalino, Cláudia Maria
collection PubMed
description Introduction: Pentavalent antimonials are the first drug of choice in the treatment of tegumentary leishmaniasis. Data on ototoxicity related with such drugs is scarcely available in literature, leading us to develop a study on cochleovestibular functions. Case Report: A case of a tegumentary leishmaniasis patient, a 78-year-old man who presented a substantial increase in auditory threshold with tinnitus and severe rotatory dizziness during the treatment with meglumine antimoniate, is reported. These symptoms worsened in two weeks after treatment was interrupted. Conclusion: Dizziness and tinnitus had already been related to meglumine antimoniate. However, this is the first well documented case of cochlear-vestibular toxicity related to meglumine antimoniate.
format Online
Article
Text
id pubmed-4172117
institution National Center for Biotechnology Information
language English
publishDate 2014
publisher Instituto de Medicina Tropical
record_format MEDLINE/PubMed
spelling pubmed-41721172014-10-28 FIRST REPORT ON OTOTOXICITY OF MEGLUMINE ANTIMONIATE Valete-Rosalino, Cláudia Maria Araujo-Melo, Maria Helena Bezerra, Débora Cristina de Oliveira de Barcelos, Renata Oliveira de Melo-Ferreira, Vanessa Torraca, Tânia Salgado de Sousa Martins, Ana Cristina da Costa Moreira, João Soares Vargas, Mirian Catherine Melgares Braga, Frederico Pereira Bom Salgueiro, Mariza de Matos Saheki, Maurício Naoto Schubach, Armando Oliveira Rev Inst Med Trop Sao Paulo Case Report Introduction: Pentavalent antimonials are the first drug of choice in the treatment of tegumentary leishmaniasis. Data on ototoxicity related with such drugs is scarcely available in literature, leading us to develop a study on cochleovestibular functions. Case Report: A case of a tegumentary leishmaniasis patient, a 78-year-old man who presented a substantial increase in auditory threshold with tinnitus and severe rotatory dizziness during the treatment with meglumine antimoniate, is reported. These symptoms worsened in two weeks after treatment was interrupted. Conclusion: Dizziness and tinnitus had already been related to meglumine antimoniate. However, this is the first well documented case of cochlear-vestibular toxicity related to meglumine antimoniate. Instituto de Medicina Tropical 2014 /pmc/articles/PMC4172117/ /pubmed/25229226 http://dx.doi.org/10.1590/S0036-46652014000500012 Text en http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Valete-Rosalino, Cláudia Maria
Araujo-Melo, Maria Helena
Bezerra, Débora Cristina de Oliveira
de Barcelos, Renata Oliveira
de Melo-Ferreira, Vanessa
Torraca, Tânia Salgado de Sousa
Martins, Ana Cristina da Costa
Moreira, João Soares
Vargas, Mirian Catherine Melgares
Braga, Frederico Pereira Bom
Salgueiro, Mariza de Matos
Saheki, Maurício Naoto
Schubach, Armando Oliveira
FIRST REPORT ON OTOTOXICITY OF MEGLUMINE ANTIMONIATE
title FIRST REPORT ON OTOTOXICITY OF MEGLUMINE ANTIMONIATE
title_full FIRST REPORT ON OTOTOXICITY OF MEGLUMINE ANTIMONIATE
title_fullStr FIRST REPORT ON OTOTOXICITY OF MEGLUMINE ANTIMONIATE
title_full_unstemmed FIRST REPORT ON OTOTOXICITY OF MEGLUMINE ANTIMONIATE
title_short FIRST REPORT ON OTOTOXICITY OF MEGLUMINE ANTIMONIATE
title_sort first report on ototoxicity of meglumine antimoniate
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4172117/
https://www.ncbi.nlm.nih.gov/pubmed/25229226
http://dx.doi.org/10.1590/S0036-46652014000500012
work_keys_str_mv AT valeterosalinoclaudiamaria firstreportonototoxicityofmeglumineantimoniate
AT araujomelomariahelena firstreportonototoxicityofmeglumineantimoniate
AT bezerradeboracristinadeoliveira firstreportonototoxicityofmeglumineantimoniate
AT debarcelosrenataoliveira firstreportonototoxicityofmeglumineantimoniate
AT demeloferreiravanessa firstreportonototoxicityofmeglumineantimoniate
AT torracataniasalgadodesousa firstreportonototoxicityofmeglumineantimoniate
AT martinsanacristinadacosta firstreportonototoxicityofmeglumineantimoniate
AT moreirajoaosoares firstreportonototoxicityofmeglumineantimoniate
AT vargasmiriancatherinemelgares firstreportonototoxicityofmeglumineantimoniate
AT bragafredericopereirabom firstreportonototoxicityofmeglumineantimoniate
AT salgueiromarizadematos firstreportonototoxicityofmeglumineantimoniate
AT sahekimauricionaoto firstreportonototoxicityofmeglumineantimoniate
AT schubacharmandooliveira firstreportonototoxicityofmeglumineantimoniate

Ejemplares similares