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Comparison of process parameter optimization using different designs in nanoemulsion-based formulation for transdermal delivery of fullerene
This research aims to formulate and to optimize a nanoemulsion-based formulation containing fullerene, an antioxidant, stabilized by a low amount of mixed surfactants using high shear and the ultrasonic emulsification method for transdermal delivery. Process parameters optimization of fullerene nano...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Dove Medical Press
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4172124/ https://www.ncbi.nlm.nih.gov/pubmed/25258528 http://dx.doi.org/10.2147/IJN.S65689 |
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author | Ngan, Cheng Loong Basri, Mahiran Lye, Fui Fang Fard Masoumi, Hamid Reza Tripathy, Minaketan Karjiban, Roghayeh Abedi Abdul-Malek, Emilia |
author_facet | Ngan, Cheng Loong Basri, Mahiran Lye, Fui Fang Fard Masoumi, Hamid Reza Tripathy, Minaketan Karjiban, Roghayeh Abedi Abdul-Malek, Emilia |
author_sort | Ngan, Cheng Loong |
collection | PubMed |
description | This research aims to formulate and to optimize a nanoemulsion-based formulation containing fullerene, an antioxidant, stabilized by a low amount of mixed surfactants using high shear and the ultrasonic emulsification method for transdermal delivery. Process parameters optimization of fullerene nanoemulsions was done by employing response surface methodology, which involved statistical multivariate analysis. Optimization of independent variables was investigated using experimental design based on Box–Behnken design and central composite rotatable design. An investigation on the effect of the homogenization rate (4,000–5,000 rpm), sonication amplitude (20%–60%), and sonication time (30–150 seconds) on the particle size, ζ-potential, and viscosity of the colloidal systems was conducted. Under the optimum conditions, the central composite rotatable design model suggested the response variables for particle size, ζ-potential, and viscosity of the fullerene nanoemulsion were 152.5 nm, −52.6 mV, and 44.6 pascal seconds, respectively. In contrast, the Box–Behnken design model proposed that preparation under the optimum condition would produce nanoemulsion with particle size, ζ-potential, and viscosity of 148.5 nm, −55.2 mV, and 39.9 pascal seconds, respectively. The suggested process parameters to obtain optimum formulation by both models yielded actual response values similar to the predicted values with residual standard error of <2%. The optimum formulation showed more elastic and solid-like characteristics due to the existence of a large linear viscoelastic region. |
format | Online Article Text |
id | pubmed-4172124 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Dove Medical Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-41721242014-09-25 Comparison of process parameter optimization using different designs in nanoemulsion-based formulation for transdermal delivery of fullerene Ngan, Cheng Loong Basri, Mahiran Lye, Fui Fang Fard Masoumi, Hamid Reza Tripathy, Minaketan Karjiban, Roghayeh Abedi Abdul-Malek, Emilia Int J Nanomedicine Original Research This research aims to formulate and to optimize a nanoemulsion-based formulation containing fullerene, an antioxidant, stabilized by a low amount of mixed surfactants using high shear and the ultrasonic emulsification method for transdermal delivery. Process parameters optimization of fullerene nanoemulsions was done by employing response surface methodology, which involved statistical multivariate analysis. Optimization of independent variables was investigated using experimental design based on Box–Behnken design and central composite rotatable design. An investigation on the effect of the homogenization rate (4,000–5,000 rpm), sonication amplitude (20%–60%), and sonication time (30–150 seconds) on the particle size, ζ-potential, and viscosity of the colloidal systems was conducted. Under the optimum conditions, the central composite rotatable design model suggested the response variables for particle size, ζ-potential, and viscosity of the fullerene nanoemulsion were 152.5 nm, −52.6 mV, and 44.6 pascal seconds, respectively. In contrast, the Box–Behnken design model proposed that preparation under the optimum condition would produce nanoemulsion with particle size, ζ-potential, and viscosity of 148.5 nm, −55.2 mV, and 39.9 pascal seconds, respectively. The suggested process parameters to obtain optimum formulation by both models yielded actual response values similar to the predicted values with residual standard error of <2%. The optimum formulation showed more elastic and solid-like characteristics due to the existence of a large linear viscoelastic region. Dove Medical Press 2014-09-15 /pmc/articles/PMC4172124/ /pubmed/25258528 http://dx.doi.org/10.2147/IJN.S65689 Text en © 2014 Ngan et al. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. |
spellingShingle | Original Research Ngan, Cheng Loong Basri, Mahiran Lye, Fui Fang Fard Masoumi, Hamid Reza Tripathy, Minaketan Karjiban, Roghayeh Abedi Abdul-Malek, Emilia Comparison of process parameter optimization using different designs in nanoemulsion-based formulation for transdermal delivery of fullerene |
title | Comparison of process parameter optimization using different designs in nanoemulsion-based formulation for transdermal delivery of fullerene |
title_full | Comparison of process parameter optimization using different designs in nanoemulsion-based formulation for transdermal delivery of fullerene |
title_fullStr | Comparison of process parameter optimization using different designs in nanoemulsion-based formulation for transdermal delivery of fullerene |
title_full_unstemmed | Comparison of process parameter optimization using different designs in nanoemulsion-based formulation for transdermal delivery of fullerene |
title_short | Comparison of process parameter optimization using different designs in nanoemulsion-based formulation for transdermal delivery of fullerene |
title_sort | comparison of process parameter optimization using different designs in nanoemulsion-based formulation for transdermal delivery of fullerene |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4172124/ https://www.ncbi.nlm.nih.gov/pubmed/25258528 http://dx.doi.org/10.2147/IJN.S65689 |
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