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Nanotetrac targets integrin αvβ3 on tumor cells to disorder cell defense pathways and block angiogenesis
The extracellular domain of integrin αvβ3 contains a receptor for thyroid hormone and hormone analogs. The integrin is amply expressed by tumor cells and dividing blood vessel cells. The proangiogenic properties of thyroid hormone and the capacity of the hormone to promote cancer cell proliferation...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Dove Medical Press
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4172128/ https://www.ncbi.nlm.nih.gov/pubmed/25258542 http://dx.doi.org/10.2147/OTT.S67393 |