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Rationally Designed, Nontoxic, Nonamyloidogenic Analogues of Human Islet Amyloid Polypeptide with Improved Solubility

[Image: see text] Human islet amyloid polypeptide (hIAPP or amylin) is a polypeptide hormone produced in the pancreatic β-cells that plays a role in glycemic control. hIAPP is deficient in type 1 and type 2 diabetes and is a promising adjunct to insulin therapy. However, hIAPP rapidly forms amyloid,...

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Detalles Bibliográficos
Autores principales:	Wang, Hui, Abedini, Andisheh, Ruzsicska, Bela, Raleigh, Daniel P.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2014
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4172205/ https://www.ncbi.nlm.nih.gov/pubmed/25140605 http://dx.doi.org/10.1021/bi500592p

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