Early retinal neurodegeneration and impaired Ran-mediated nuclear import of TDP-43 in progranulin-deficient FTLD

Frontotemporal dementia (FTD) is the most common cause of dementia in people under 60 yr of age and is pathologically associated with mislocalization of TAR DNA/RNA binding protein 43 (TDP-43) in approximately half of cases (FLTD-TDP). Mutations in the gene encoding progranulin (GRN), which lead to...

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Detalles Bibliográficos
Autores principales: Ward, Michael E., Taubes, Alice, Chen, Robert, Miller, Bruce L., Sephton, Chantelle F., Gelfand, Jeffrey M., Minami, Sakura, Boscardin, John, Martens, Lauren Herl, Seeley, William W., Yu, Gang, Herz, Joachim, Filiano, Anthony J., Arrant, Andrew E., Roberson, Erik D., Kraft, Timothy W., Farese, Robert V., Green, Ari, Gan, Li
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2014
Materias:
Brief Definitive Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4172214/
https://www.ncbi.nlm.nih.gov/pubmed/25155018
http://dx.doi.org/10.1084/jem.20140214

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