IKK-induced NF-κB1 p105 proteolysis is critical for B cell antibody responses to T cell–dependent antigen

The importance of IκB kinase (IKK)–induced proteolysis of NF-κB1 p105 in B cells was investigated using Nfkb1(SSAA/SSAA) mice, in which this NF-κB signaling pathway is blocked. Nfkb1(SSAA) mutation had no effect on the development and homeostasis of follicular mature (FM) B cells. However, analysis...

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Detalles Bibliográficos
Autores principales: Jacque, Emilie, Schweighoffer, Edina, Visekruna, Alexander, Papoutsopoulou, Stamatia, Janzen, Julia, Zillwood, Rachel, Tarlinton, David M., Tybulewicz, Victor L.J., Ley, Steven C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4172221/
https://www.ncbi.nlm.nih.gov/pubmed/25225457
http://dx.doi.org/10.1084/jem.20132019

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4172221/
https://www.ncbi.nlm.nih.gov/pubmed/25225457
http://dx.doi.org/10.1084/jem.20132019

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