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Cancer-promoting and Inhibiting Effects of Dietary Compounds: Role of the Aryl Hydrocarbon Receptor (AhR)

Polyaromatic hydrocarbons, heterocyclic aromatic amines and dioxin-like compounds are environmental carcinogens shown to initiate cancer in a number of tissue types including prostate and breast. These environmental carcinogens elicit their effects through interacting with the aryl hydrocarbon recep...

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Detalles Bibliográficos
Autores principales: Powell, Joann B., Ghotbaddini, Maryam
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4172379/
https://www.ncbi.nlm.nih.gov/pubmed/25258701
http://dx.doi.org/10.4172/2167-0501.1000131
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author Powell, Joann B.
Ghotbaddini, Maryam
author_facet Powell, Joann B.
Ghotbaddini, Maryam
author_sort Powell, Joann B.
collection PubMed
description Polyaromatic hydrocarbons, heterocyclic aromatic amines and dioxin-like compounds are environmental carcinogens shown to initiate cancer in a number of tissue types including prostate and breast. These environmental carcinogens elicit their effects through interacting with the aryl hydrocarbon receptor (AhR), a ligand activated transcription factor. Naturally occurring compounds found in fruits and vegetables shown to have anti-carcinogenic effects also interact with the AhR. This review explores dietary and environmental exposure to chemical carcinogens and beneficial natural compounds whose effects are elicited by the AhR.
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spelling pubmed-41723792014-09-23 Cancer-promoting and Inhibiting Effects of Dietary Compounds: Role of the Aryl Hydrocarbon Receptor (AhR) Powell, Joann B. Ghotbaddini, Maryam Biochem Pharmacol (Los Angel) Article Polyaromatic hydrocarbons, heterocyclic aromatic amines and dioxin-like compounds are environmental carcinogens shown to initiate cancer in a number of tissue types including prostate and breast. These environmental carcinogens elicit their effects through interacting with the aryl hydrocarbon receptor (AhR), a ligand activated transcription factor. Naturally occurring compounds found in fruits and vegetables shown to have anti-carcinogenic effects also interact with the AhR. This review explores dietary and environmental exposure to chemical carcinogens and beneficial natural compounds whose effects are elicited by the AhR. 2014-03-08 /pmc/articles/PMC4172379/ /pubmed/25258701 http://dx.doi.org/10.4172/2167-0501.1000131 Text en Copyright: © 2014 Powell JB, et al. http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Article
Powell, Joann B.
Ghotbaddini, Maryam
Cancer-promoting and Inhibiting Effects of Dietary Compounds: Role of the Aryl Hydrocarbon Receptor (AhR)
title Cancer-promoting and Inhibiting Effects of Dietary Compounds: Role of the Aryl Hydrocarbon Receptor (AhR)
title_full Cancer-promoting and Inhibiting Effects of Dietary Compounds: Role of the Aryl Hydrocarbon Receptor (AhR)
title_fullStr Cancer-promoting and Inhibiting Effects of Dietary Compounds: Role of the Aryl Hydrocarbon Receptor (AhR)
title_full_unstemmed Cancer-promoting and Inhibiting Effects of Dietary Compounds: Role of the Aryl Hydrocarbon Receptor (AhR)
title_short Cancer-promoting and Inhibiting Effects of Dietary Compounds: Role of the Aryl Hydrocarbon Receptor (AhR)
title_sort cancer-promoting and inhibiting effects of dietary compounds: role of the aryl hydrocarbon receptor (ahr)
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4172379/
https://www.ncbi.nlm.nih.gov/pubmed/25258701
http://dx.doi.org/10.4172/2167-0501.1000131
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