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mTORC1 drives HIF-1α and VEGF-A signalling via multiple mechanisms involving 4E-BP1, S6K1 and STAT3

Recent clinical trials using rapalogues in tuberous sclerosis complex (TSC) show regression in volume of typically vascularised tumours including angiomyolipomas (AMLs) and sub-ependymal giant cell astrocytomas (SEGAs). By blocking mechanistic/mammalian target of rapamycin complex 1 (mTORC1) signall...

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Detalles Bibliográficos
Autores principales:	Dodd, Kayleigh M., Yang, Jian, Shen, Ming Hong, Sampson, Julian R., Tee, Andrew R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2014
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4172452/ https://www.ncbi.nlm.nih.gov/pubmed/24931163 http://dx.doi.org/10.1038/onc.2014.164

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