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Role of Ser102 and Ser104 as Regulators of cGMP Hydrolysis by PDE5A
BACKGROUND: Phosphodiesterases (PDEs) cleave phosphodiester bonds in cyclic nucleotides and play diverse roles in cell biology. PDE5A is a cytoplasmic phosphodiesterase which specifically degrades cyclic guanosine monophosphate (cGMP), a cell signaling molecule that plays important roles in neuronal...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Public Library of Science
2014
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4172485/ https://www.ncbi.nlm.nih.gov/pubmed/25247292 http://dx.doi.org/10.1371/journal.pone.0107627 |