SRT2104 extends survival of male mice on a standard diet and preserves bone and muscle mass

Increased expression of SIRT1 extends the lifespan of lower organisms and delays the onset of age-related diseases in mammals. Here, we show that SRT2104, a synthetic small molecule activator of SIRT1, extends both mean and maximal lifespan of mice fed a standard diet. This is accompanied by improve...

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Detalles Bibliográficos
Autores principales: Mercken, Evi M, Mitchell, Sarah J, Martin-Montalvo, Alejandro, Minor, Robin K, Almeida, Maria, Gomes, Ana P, Scheibye-Knudsen, Morten, Palacios, Hector H, Licata, Jordan J, Zhang, Yongqing, Becker, Kevin G, Khraiwesh, Husam, González-Reyes, José A, Villalba, José M, Baur, Joseph A, Elliott, Peter, Westphal, Christoph, Vlasuk, George P, Ellis, James L, Sinclair, David A, Bernier, Michel, de Cabo, Rafael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BlackWell Publishing Ltd 2014
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4172519/
https://www.ncbi.nlm.nih.gov/pubmed/24931715
http://dx.doi.org/10.1111/acel.12220

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