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Depletion of Rictor, an essential protein component of mTORC2, decreases male lifespan

Rapamycin, an inhibitor of the mechanistic target of rapamycin (mTOR), robustly extends the lifespan of model organisms including mice. We recently found that chronic treatment with rapamycin not only inhibits mTOR complex 1 (mTORC1), the canonical target of rapamycin, but also inhibits mTOR complex...

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Detalles Bibliográficos
Autores principales:	Lamming, Dudley W, Mihaylova, Maria M, Katajisto, Pekka, Baar, Emma L, Yilmaz, Omer H, Hutchins, Amanda, Gultekin, Yetis, Gaither, Rachel, Sabatini, David M
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BlackWell Publishing Ltd 2014
Materias:	Original Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4172536/ https://www.ncbi.nlm.nih.gov/pubmed/25059582 http://dx.doi.org/10.1111/acel.12256

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